TY - JOUR
T1 - The utility of urinary myo-inositol as a marker of glucose intolerance
AU - Ikezaki, Hiroaki
AU - Furusyo, Norihiro
AU - Okada, Kyoko
AU - Ihara, Takeshi
AU - Hayashi, Takeo
AU - Ogawa, Eiichi
AU - Kainuma, Mosaburo
AU - Murata, Masayuki
AU - Hayashi, Jun
N1 - Funding Information:
This work was supported by the Japan Multi-institutional Collaborative Cohort Study (J-MICC Study) , a Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas (grant number 221S001 ), and a Grant-in-Aid for Comprehensive Research of the 21st Century COE Program from the Ministry of Education, Culture, Sports Science and Technology of Japan .
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Objective: The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance. Design and methods: A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2. h-UMI) glucose ingestion δ-UMI was defined as the difference between fasting UMI and 2 h-UMI. Results: δ-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened δ-UMI level was significantly positively correlated with 2 h-UMI level (r= 0.896, p< 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of δ-UMI (82.1%) and 2. h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for δ-UMI (0.903) and 2. h-UMI (0.891) were higher than that for HbA1c (0.785). Conclusions: 2. h-UMI is useful as a non-invasive screening of glucose intolerance.
AB - Objective: The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance. Design and methods: A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2. h-UMI) glucose ingestion δ-UMI was defined as the difference between fasting UMI and 2 h-UMI. Results: δ-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened δ-UMI level was significantly positively correlated with 2 h-UMI level (r= 0.896, p< 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of δ-UMI (82.1%) and 2. h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for δ-UMI (0.903) and 2. h-UMI (0.891) were higher than that for HbA1c (0.785). Conclusions: 2. h-UMI is useful as a non-invasive screening of glucose intolerance.
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U2 - 10.1016/j.diabres.2013.11.018
DO - 10.1016/j.diabres.2013.11.018
M3 - Article
C2 - 24377833
AN - SCOPUS:84893665203
VL - 103
SP - 88
EP - 96
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -
