Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

Nobuaki Egashira; Noriko Ishigami; Fengling Pu; Kenichi Mishima; Katsunori Iwasaki; Kensuke Orito; Ryozo Oishi; Michihiro Fujiwara

doi:10.1002/ptr.2261

Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

Nobuaki Egashira, Noriko Ishigami, Fengling Pu, Kenichi Mishima, Katsunori Iwasaki, Kensuke Orito, Ryozo Oishi, Michihiro Fujiwara

Pharmacy

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The present study investigated the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Phytotherapy Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/ptr.2261
Publication status	Published - Jan 1 2008

All Science Journal Classification (ASJC) codes

Pharmacology

Access to Document

10.1002/ptr.2261

Cite this

@article{e640094d86634df19f5f3d68f0747d57,

title = "Theanine prevents memory impairment induced by repeated cerebral ischemia in rats",

abstract = "The present study investigated the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease.",

author = "Nobuaki Egashira and Noriko Ishigami and Fengling Pu and Kenichi Mishima and Katsunori Iwasaki and Kensuke Orito and Ryozo Oishi and Michihiro Fujiwara",

year = "2008",

month = jan,

day = "1",

doi = "10.1002/ptr.2261",

language = "English",

volume = "22",

pages = "65--68",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "1",

}

TY - JOUR

T1 - Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

AU - Egashira, Nobuaki

AU - Ishigami, Noriko

AU - Pu, Fengling

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Orito, Kensuke

AU - Oishi, Ryozo

AU - Fujiwara, Michihiro

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The present study investigated the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease.

AB - The present study investigated the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=38549170007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38549170007&partnerID=8YFLogxK

U2 - 10.1002/ptr.2261

DO - 10.1002/ptr.2261

M3 - Article

C2 - 17705146

AN - SCOPUS:38549170007

SN - 0951-418X

VL - 22

SP - 65

EP - 68

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 1

ER -

Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this