Theanine prevents memory impairment induced by repeated cerebral ischemia in rats

Nobuaki Egashira, Noriko Ishigami, Fengling Pu, Kenichi Mishima, Katsunori Iwasaki, Kensuke Orito, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The present study investigated the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice-repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalPhytotherapy Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology

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