Theoretical analysis on the relationship between left ventricular energetic efficiency and acute infarct size

Takao Shimayoshi, Yuki Hasegawa, Mitsuharu Mishima, Tetsuya Matsuda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Energetic efficiency is an important indicator of cardiac function in acute myocardial infarction. However, the relationship between cardiac energetic efficiency and infarct size is not perfectly elucidated. In this study, the relationship is analysed by means of simulation using a theoretical model of the guinea pig left ventricle. In simulation with varied ratios of infarct area, pressure-volume area (PVA), which is an index of total mechanical energy by ventricular contraction, and myocardial oxygen consumption (MVO2) are calculated for each infarct ratio. Then, change of PVA when MVO2 alters (PVA/MVO2) as a well-known index of energy conversion efficiency is evaluated. In addition, PVA/VO2, which represents a ratio of PVA change to alteration of mean oxygen consumption of myocytes except for infarct myocytes, is introduced as an index for real energetic efficiency. In simulation results, PVA/MVO2 increases but PVA/VO2 decreases as infarct area expands, because with expansion of infarct area PVA decreases but VO2 remains almost unchanged because of larger shortening of myocytes. This implies that the enlargement of shortening of noninfarcted myocyte to compensate for depression of cardiac output is a potential cause of myocardial remodelling.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalIET Systems Biology
Volume7
Issue number3
DOIs
Publication statusPublished - Dec 1 2013
Externally publishedYes

Fingerprint

Infarct Size
Acute
Theoretical Analysis
Pressure
Myocytes
Muscle Cells
Oxygen Consumption
Myocardial Contraction
Cardiac
Oxygen
Relationships
Energy conversion
Cardiac Output
Conversion efficiency
Acute Myocardial Infarction
Heart Ventricles
Guinea pig
Decrease
Remodeling
Simulation

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Modelling and Simulation

Cite this

Theoretical analysis on the relationship between left ventricular energetic efficiency and acute infarct size. / Shimayoshi, Takao; Hasegawa, Yuki; Mishima, Mitsuharu; Matsuda, Tetsuya.

In: IET Systems Biology, Vol. 7, No. 3, 01.12.2013, p. 74-78.

Research output: Contribution to journalArticle

Shimayoshi, Takao ; Hasegawa, Yuki ; Mishima, Mitsuharu ; Matsuda, Tetsuya. / Theoretical analysis on the relationship between left ventricular energetic efficiency and acute infarct size. In: IET Systems Biology. 2013 ; Vol. 7, No. 3. pp. 74-78.
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