Theranostic nanoparticles for MRI-guided thermochemotherapy: "tight" clustering of magnetic nanoparticles boosts relaxivity and heat-generation power

Koichiro Hayashi, Yoshitaka Sato, Wataru Sakamoto, Toshinobu Yogo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Magnetic-resonance-imaging (MRI)-guided magnetic thermochemotherapy is a potentially invasive technique combining diagnosis and treatment. It requires the development of multifunctional nanoparticles with (1) biocompatibility, (2) high relaxivity, (3) high heat-generation power, (4) controlled drug release, and (5) tumor targeting. Here, we show the synthesis of such multifunctional nanoparticles ("Core-Shells") and the feasibility of MRI-guided magnetic thermochemotherapy using the synthesized nanoparticles. "Tight" iron-oxide nanoparticle clustering to zero interparticle distance within the Core-Shells boosts the relaxivity and heat-generation power while maintaining biocompatibility. The initial Core-Shell drug release occurs in response to an alternating magnetic field (AMF) and continues gradually after removal of the AMF. Thus, a single Core-Shell dose realizes continuous chemotherapy over a period of days or weeks. The Core-Shells accumulate in abdomen tumors, facilitating MRI visualization. Subsequent AMF application induces heat generation and drug release within the tumors, inhibiting their growth. Core-Shell magnetic thermochemotherapy exhibits significantly higher therapeutic efficacy than both magnetic hyperthermia and chemotherapy alone. More importantly, there are minimal side effects. The findings of this study introduce new perspectives regarding the development of materials for MRI, magnetic hyperthermia, and drug delivery systems. Both conventional and novel iron-oxide-based materials may render theranostics (i.e., techniques fusing diagnosis and treatment) feasible.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalACS Biomaterials Science and Engineering
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 1 2017
Externally publishedYes

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Heat generation
Magnetic resonance imaging
Nanoparticles
Tumors
Chemotherapy
Magnetic fields
Iron oxides
Biocompatibility
Pharmaceutical Preparations
Visualization
ferric oxide

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Theranostic nanoparticles for MRI-guided thermochemotherapy : "tight" clustering of magnetic nanoparticles boosts relaxivity and heat-generation power. / Hayashi, Koichiro; Sato, Yoshitaka; Sakamoto, Wataru; Yogo, Toshinobu.

In: ACS Biomaterials Science and Engineering, Vol. 3, No. 1, 01.01.2017, p. 95-105.

Research output: Contribution to journalArticle

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