Therapeutic and clinical applications of nitroxide compounds

Benjamin P. Soule, Fuminori Hyodo, Ken Ichiro Matsumoto, Nicole L. Simone, John A. Cook, Murali C. Krishna, James B. Mitchell

Research output: Contribution to journalReview articlepeer-review

108 Citations (Scopus)

Abstract

Nitroxide compounds have been used for many years as biophysical tools, but only during the past 15-20 years have the many interesting biochemical interactions been discovered and harnessed for therapeutic applications. By modifying oxidative stress and altering the redox status of tissues, nitroxides have the ability to interact with and alter many metabolic processes. This interaction can be exploited for therapeutic and research use, including protection against ionizing radiation, as probes in functional magnetic resonance imaging, cancer prevention and treatment, control of hypertension and weight, and protection from damage resulting from ischemia/reperfusion injury. Although much remains to be done, many applications have been well studied, and some are presently being tested in clinical trials. The therapeutic and research uses of nitroxides are reviewed here, with a focus on the progress from initial development to modern, state-of-the art trials.

Original languageEnglish
Pages (from-to)1731-1743
Number of pages13
JournalAntioxidants and Redox Signaling
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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