Therapeutic effects of hydrogen in animal models of Parkinson's disease

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Since the first description of Parkinson's disease (PD) nearly two centuries ago, a number of studies have revealed the clinical symptoms, pathology, and therapeutic approaches to overcome this intractable neurodegenerative disease. 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA) are neurotoxins which produce Parkinsonian pathology. From the animal studies using these neurotoxins, it has become well established that oxidative stress is a primary cause of, and essential for, cellular apoptosis in dopaminergic neurons. Here, we describe the mechanism whereby oxidative stress evokes irreversible cell death, and propose a novel therapeutic strategy for PD using molecular hydrogen. Hydrogen has an ability to reduce oxidative damage and ameliorate the loss of nigrostriatal dopaminergic neuronal pathway in two experimental animal models. Thus, it is strongly suggested that hydrogen might provide a great advantage to prevent or minimize the onset and progression of PD.

Original languageEnglish
Article number307875
JournalParkinson's Disease
DOIs
Publication statusPublished - Sep 19 2011

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Therapeutic Uses
Parkinson Disease
Hydrogen
Animal Models
Oxidopamine
Neurotoxins
Oxidative Stress
Clinical Pathology
Dopaminergic Neurons
Neurodegenerative Diseases
Cell Death
Apoptosis
Pathology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Therapeutic effects of hydrogen in animal models of Parkinson's disease. / Fujita, Kyota; Nakabeppu, Yusaku; Noda, Mami.

In: Parkinson's Disease, 19.09.2011.

Research output: Contribution to journalReview article

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