TY - JOUR
T1 - Therapeutic implication targeting for cancer stem cells
AU - Noguchi, Kozo
AU - Konno, Masamitsu
AU - Nishida, Naohiro
AU - Kawamoto, Koichi
AU - Koseki, Jun
AU - Eguchi, Hidetoshi
AU - Doki, Yuichiro
AU - Mori, Masaki
AU - Satoh, Taro
AU - Ishii, Hideshi
PY - 2015/9
Y1 - 2015/9
N2 - Cancer has been viewed as a heterogeneous population of cells. While the large majority of cells that constituting tumors are differentiated, and eventually stop dividing, only a minority population of cells, termed cancer stem cells, is capable of unlimited self-renewal and multi-differentiation, just like somatic stem cells in normal tissues. Cancer stem cells have been identified in a variety of cancers of the blood, brain, stomach, colon, and pancreas. In this review we present current evidence supporting the cancer stem cell model of tumor progression, and discuss the experimental and therapeutic implications.
AB - Cancer has been viewed as a heterogeneous population of cells. While the large majority of cells that constituting tumors are differentiated, and eventually stop dividing, only a minority population of cells, termed cancer stem cells, is capable of unlimited self-renewal and multi-differentiation, just like somatic stem cells in normal tissues. Cancer stem cells have been identified in a variety of cancers of the blood, brain, stomach, colon, and pancreas. In this review we present current evidence supporting the cancer stem cell model of tumor progression, and discuss the experimental and therapeutic implications.
UR - http://www.scopus.com/inward/record.url?scp=84952903461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952903461&partnerID=8YFLogxK
M3 - Article
C2 - 26469158
AN - SCOPUS:84952903461
SN - 0385-0684
VL - 42
SP - 1036
EP - 1039
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 9
ER -
