Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan

Kouji Tsugawa, Nobuhiro Koyanagi, Makoto Hashizume, Kazuya Akahoshi, Hiroya Wada, Katsuhiko Ayukawa, Morimasa Tomikawa, Keizo Sugimachi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Aims: The prognosis for colon cancer is poorest in cases of emergency situation in the elderly not only in Japan, but worldwide. The aim was to design a therapeutic approach used for colon cancer in the elderly. Methodology: Seventy-one patients, who were all older than 70 years, with colon carcinoma in an emergency situation were examined. Lethality, surgical procedure, risk of comorbidity, multiple organ system failure and the effect of endotoxin absorption were examined. Results: Any increase in comorbidity was associated with a higher clinical lethality in the lungs, heart, kidney, and diabetes. The highest postoperative mortality rate was recorded in patients who underwent primary resection after perforation, while the lowest postoperative mortality rate was recorded in patients who underwent primary resection after obstruction. Postoperative failure of the lungs and heart and renal failure were associated with a significantly higher mortality rate. Twenty-five septic patients received an endotoxin adsorption due to blood filtration and 8 patients survived. Of the eight survivors, the endotoxin concentration was significantly decreased by an endotoxin absorption. Conclusions: In cases of ileus, the resection may be performed positively. In cases of perforation, we may safely say now that stoma and resection is to be recommended. Endotoxin absorption due to blood filtration may be an effective additional therapy for postoperative septic shock.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalHepato-gastroenterology
Volume49
Issue number44
Publication statusPublished - Jan 1 2002

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Endotoxins
Colonic Neoplasms
Japan
Emergencies
Mortality
Comorbidity
Therapeutics
Lung
Multiple Organ Failure
Ileus
Septic Shock
Adsorption
Renal Insufficiency
Survivors
Colon
Heart Failure
Carcinoma
Kidney

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Tsugawa, K., Koyanagi, N., Hashizume, M., Akahoshi, K., Wada, H., Ayukawa, K., ... Sugimachi, K. (2002). Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan. Hepato-gastroenterology, 49(44), 393-398.

Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan. / Tsugawa, Kouji; Koyanagi, Nobuhiro; Hashizume, Makoto; Akahoshi, Kazuya; Wada, Hiroya; Ayukawa, Katsuhiko; Tomikawa, Morimasa; Sugimachi, Keizo.

In: Hepato-gastroenterology, Vol. 49, No. 44, 01.01.2002, p. 393-398.

Research output: Contribution to journalArticle

Tsugawa, K, Koyanagi, N, Hashizume, M, Akahoshi, K, Wada, H, Ayukawa, K, Tomikawa, M & Sugimachi, K 2002, 'Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan', Hepato-gastroenterology, vol. 49, no. 44, pp. 393-398.
Tsugawa K, Koyanagi N, Hashizume M, Akahoshi K, Wada H, Ayukawa K et al. Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan. Hepato-gastroenterology. 2002 Jan 1;49(44):393-398.
Tsugawa, Kouji ; Koyanagi, Nobuhiro ; Hashizume, Makoto ; Akahoshi, Kazuya ; Wada, Hiroya ; Ayukawa, Katsuhiko ; Tomikawa, Morimasa ; Sugimachi, Keizo. / Therapeutic strategy of emergency surgery for colon cancer in 71 patients over 70 years of age in Japan. In: Hepato-gastroenterology. 2002 ; Vol. 49, No. 44. pp. 393-398.
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