Abstract
A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 767-768 |
| Number of pages | 2 |
| Journal | Chemistry Letters |
| Volume | 42 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 15 2013 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
Cite this
Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods. / Sakamura, Yuki; Yoshiura, Moemi; Tang, Hengmin; Mori, Takeshi; Katayama, Yoshiki; Niidome, Takuro.
In: Chemistry Letters, Vol. 42, No. 7, 15.07.2013, p. 767-768.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods
AU - Sakamura, Yuki
AU - Yoshiura, Moemi
AU - Tang, Hengmin
AU - Mori, Takeshi
AU - Katayama, Yoshiki
AU - Niidome, Takuro
PY - 2013/7/15
Y1 - 2013/7/15
N2 - A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.
AB - A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.
UR - http://www.scopus.com/inward/record.url?scp=84879937417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879937417&partnerID=8YFLogxK
U2 - 10.1246/cl.130220
DO - 10.1246/cl.130220
M3 - Article
AN - SCOPUS:84879937417
VL - 42
SP - 767
EP - 768
JO - Chemistry Letters
JF - Chemistry Letters
SN - 0366-7022
IS - 7
ER -