Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods

Yuki Sakamura, Moemi Yoshiura, Hengmin Tang, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.

Original languageEnglish
Pages (from-to)767-768
Number of pages2
JournalChemistry Letters
Volume42
Issue number7
DOIs
Publication statusPublished - Jul 15 2013

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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