Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods

Yuki Sakamura, Moemi Yoshiura, Hengmin Tang, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.

    Original languageEnglish
    Pages (from-to)767-768
    Number of pages2
    JournalChemistry Letters
    Volume42
    Issue number7
    DOIs
    Publication statusPublished - 2013

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)

    Fingerprint

    Dive into the research topics of 'Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods'. Together they form a unique fingerprint.

    Cite this