Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods

Yuki Sakamura; Moemi Yoshiura; Hengmin Tang; Takeshi Mori; Yoshiki Katayama; Takuro Niidome

doi:10.1246/cl.130220

Thermal enhancement of gene transfection in tumor cells mediated by the photothermal effect of gold nanorods

Yuki Sakamura, Moemi Yoshiura, Hengmin Tang, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

Materials Science and Engineering, School of Engineering

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.

Original language	English
Pages (from-to)	767-768
Number of pages	2
Journal	Chemistry Letters
Volume	42
Issue number	7
DOIs	https://doi.org/10.1246/cl.130220
Publication status	Published - Jul 15 2013

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.130220

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abstract = "A plasmid DNA and gold nanorods were directly injected to tumor in mice, and the tumor was heated to 3942 °C through the photothermal effect of the gold nanorods. The heat treatment enhanced transgene expression from the plasmid DNA in the tumor and induced heat shock protein HSP70, related to several immune responses. This transfection technique combined with heat treatment will be applicable to DNA vaccination and gene therapy for immunological diseases.",

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AU - Katayama, Yoshiki

AU - Niidome, Takuro

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