Thermo responsive DNA/polymer conjugate for intelligent antisense strategy

Masaharu Murata; Wataru Kaku; Takahisa Anada; Nobuaki Soh; Yoshiki Katayama; Mizuo Maeda

doi:10.1246/cl.2003.266

Thermo responsive DNA/polymer conjugate for intelligent antisense strategy

Masaharu Murata, Wataru Kaku, Takahisa Anada, Nobuaki Soh, Yoshiki Katayama, Mizuo Maeda

Department of Soft Materials Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.

Original language	English
Pages (from-to)	266-267
Number of pages	2
Journal	Chemistry Letters
Volume	32
Issue number	3
DOIs	https://doi.org/10.1246/cl.2003.266
Publication status	Published - Mar 5 2003

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.2003.266

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title = "Thermo responsive DNA/polymer conjugate for intelligent antisense strategy",

abstract = "The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.",

author = "Masaharu Murata and Wataru Kaku and Takahisa Anada and Nobuaki Soh and Yoshiki Katayama and Mizuo Maeda",

year = "2003",

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doi = "10.1246/cl.2003.266",

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AU - Murata, Masaharu

AU - Kaku, Wataru

AU - Anada, Takahisa

AU - Soh, Nobuaki

AU - Katayama, Yoshiki

AU - Maeda, Mizuo

PY - 2003/3/5

Y1 - 2003/3/5

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AB - The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.

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Thermo responsive DNA/polymer conjugate for intelligent antisense strategy

Abstract

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