Thermo responsive DNA/polymer conjugate for intelligent antisense strategy

Masaharu Murata, Wataru Kaku, Takahisa Anada, Nobuaki Soh, Yoshiki Katayama, Mizuo Maeda

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.

Original languageEnglish
Pages (from-to)266-267
Number of pages2
JournalChemistry Letters
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 5 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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