Thermo responsive DNA/polymer conjugate for intelligent antisense strategy

Masaharu Murata, Wataru Kaku, Takahisa Anada, Nobuaki Soh, Yoshiki Katayama, Mizuo Maeda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The conjugate between 20-mer antisense oligodeoxynucleotides (ODN) and thermo-responsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), was prepared. Hybridization reaction between the conjugate and their target RNA was modulated by conformational change of polymer moiety depending on temperature condition.

Original languageEnglish
Pages (from-to)266-267
Number of pages2
JournalChemistry Letters
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 5 2003

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Polymers
Oligodeoxyribonucleotides
DNA
RNA
Temperature
poly-N-isopropylacrylamide

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Thermo responsive DNA/polymer conjugate for intelligent antisense strategy. / Murata, Masaharu; Kaku, Wataru; Anada, Takahisa; Soh, Nobuaki; Katayama, Yoshiki; Maeda, Mizuo.

In: Chemistry Letters, Vol. 32, No. 3, 05.03.2003, p. 266-267.

Research output: Contribution to journalArticle

Murata, Masaharu ; Kaku, Wataru ; Anada, Takahisa ; Soh, Nobuaki ; Katayama, Yoshiki ; Maeda, Mizuo. / Thermo responsive DNA/polymer conjugate for intelligent antisense strategy. In: Chemistry Letters. 2003 ; Vol. 32, No. 3. pp. 266-267.
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