Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Ning Chen; Anatoly A. Zinchenko; Satoru Kidoaki; Shizuaki Murata; Kenichi Yoshikawa

doi:10.1021/la904375k

Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Ning Chen, Anatoly A. Zinchenko, Satoru Kidoaki, Shizuaki Murata, Kenichi Yoshikawa

Department of Applied Molecular Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. "With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.

Original language	English
Pages (from-to)	2995-2998
Number of pages	4
Journal	Langmuir
Volume	26
Issue number	5
DOIs	https://doi.org/10.1021/la904375k
Publication status	Published - Mar 2 2010

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la904375k

Cite this

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abstract = "We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. {"}With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.",

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AU - Chen, Ning

AU - Zinchenko, Anatoly A.

AU - Kidoaki, Satoru

AU - Murata, Shizuaki

AU - Yoshikawa, Kenichi

PY - 2010/3/2

Y1 - 2010/3/2

N2 - We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. "With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.

AB - We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. "With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.

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Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Abstract

All Science Journal Classification (ASJC) codes

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