We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. "With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.
|Number of pages||4|
|Publication status||Published - Mar 2 2010|
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
- Surfaces and Interfaces