Thermo-switching of the conformation of genomic DNA in solutions of poly(N-isopropylacrylamide)

Ning Chen, Anatoly A. Zinchenko, Satoru Kidoaki, Shizuaki Murata, Kenichi Yoshikawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We used poly(N-isopropylacrylamide) (PNIPAM) to control the conformation of genomic DNA by changing the temperature of a reaction solution and studied the DNA transition at the level of single DNA molecules. "With this method, the conformation of long genomic DNA can be readily and reversibly switched, between a very compact condensate and an unfolded macromolecule.

Original languageEnglish
Pages (from-to)2995-2998
Number of pages4
JournalLangmuir
Volume26
Issue number5
DOIs
Publication statusPublished - Mar 2 2010

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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