Thermoresponsive biointerface with a elastin model peptide

Yoshiko Miura, Yoshiyuki Yokoyama, Chieri Shibata

Research output: Contribution to journalArticle

Abstract

Lipo-VPGVG2 was synthesized by the conjugation of elastin model peptide of (Val-Pro-Gly-Val-Gly)2 and a-hpoic acid. The peptide showed some changes of conformation and water solubility in the aqueous solution. The DSC results suggested the thermoresponsive transition with temperature. The peptide of Lipo-VPGVG2 was dissolved in aqueous solution, and the gold substrate was immersed in the LipoVPGVG2 solution in order to prepare the self-assembled monolayer (SAM). The SAM formation was confirmed by FTIR, XPS, and QCM. The cell attachment of fibroblast NIH 3T3 was observed on the Lipo-VPGVG2-SAM materials prepared by the dilute peptide solutions (20 and 80 nM). The cell detachment was observed on cooling the peptide SAM at 4°C. The Lipo-VPGVG2 showed a thermoresponsive biofunction.

Original languageEnglish
Pages (from-to)584-589
Number of pages6
JournalKOBUNSHI RONBUNSHU
Volume67
Issue number10
DOIs
Publication statusPublished - Oct 1 2010

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Materials Science (miscellaneous)
  • Environmental Science(all)
  • Polymers and Plastics

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