Thermoresponsive self-assembly of short elastin-like peptides

Yoshiko Miura, Chieri Shibata, Kazukiyo Kobayahi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Short elastin-like penta- and deca- peptides have been found to self-assemble into nanofibers in a temperature dependent way. The peptides were synthesized by solid phase synthesis, modified at the N- and C-terminals respectively by acetylation and mannosylation, and analyzed in terms of thermoresponsive self-assembling. CD spectra of these peptides were indicative of conformational transition from 25 to 35°C. Dynamic light scattering (DLS) suggested that the peptides formed molecular assembly of micrometer sizes at higher temperatures. The self-assembling transition temperature was dependent on the end group modification. TEM revealed that self-assembling peptides formed ordered supramolecular nanofibers and spheres. The supramolecules of these short elastin-like peptides will be useful as novel stimuli responsive materials.

Original languageEnglish
Title of host publication54th SPSJ Symposium on Macromolecules - Polymer Preprints, Japan
Number of pages2
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sept 20 2005Sept 22 2005


Other54th SPSJ Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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