Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers

Tran Minh Quynh, Masaru Yoneyama, Yasuyuki Maki, Naotsugu Nagasawa, Toshiaki Dobashi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.

Original languageEnglish
Title of host publicationSilicon Science and Advanced Micro-Device Engineering I
Pages51-56
Number of pages6
DOIs
Publication statusPublished - Jan 20 2011
Externally publishedYes
Event5th International Symposium on Silicon Science, ISSS 2009 and the 1st International Conference on Advanced Micro-Device Engineering, AMDE 2009 - Kiryu, Japan
Duration: Dec 10 2009Dec 11 2009

Publication series

NameKey Engineering Materials
Volume459
ISSN (Print)1013-9826

Other

Other5th International Symposium on Silicon Science, ISSS 2009 and the 1st International Conference on Advanced Micro-Device Engineering, AMDE 2009
CountryJapan
CityKiryu
Period12/10/0912/11/09

Fingerprint

Graft copolymers
Micelles
Carbon Monoxide
Copolymers
Ring opening polymerization
Opacity
Homopolymerization
Atomic force microscopy
Polymerization
Nuclear magnetic resonance
hydroxyethyl methacrylate
poly(lactide)
poly-N-isopropylacrylamide
Radiation
N-isopropylacrylamide
Temperature

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Quynh, T. M., Yoneyama, M., Maki, Y., Nagasawa, N., & Dobashi, T. (2011). Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers. In Silicon Science and Advanced Micro-Device Engineering I (pp. 51-56). (Key Engineering Materials; Vol. 459). https://doi.org/10.4028/www.scientific.net/KEM.459.51

Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers. / Quynh, Tran Minh; Yoneyama, Masaru; Maki, Yasuyuki; Nagasawa, Naotsugu; Dobashi, Toshiaki.

Silicon Science and Advanced Micro-Device Engineering I. 2011. p. 51-56 (Key Engineering Materials; Vol. 459).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Quynh, TM, Yoneyama, M, Maki, Y, Nagasawa, N & Dobashi, T 2011, Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers. in Silicon Science and Advanced Micro-Device Engineering I. Key Engineering Materials, vol. 459, pp. 51-56, 5th International Symposium on Silicon Science, ISSS 2009 and the 1st International Conference on Advanced Micro-Device Engineering, AMDE 2009, Kiryu, Japan, 12/10/09. https://doi.org/10.4028/www.scientific.net/KEM.459.51
Quynh TM, Yoneyama M, Maki Y, Nagasawa N, Dobashi T. Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers. In Silicon Science and Advanced Micro-Device Engineering I. 2011. p. 51-56. (Key Engineering Materials). https://doi.org/10.4028/www.scientific.net/KEM.459.51
Quynh, Tran Minh ; Yoneyama, Masaru ; Maki, Yasuyuki ; Nagasawa, Naotsugu ; Dobashi, Toshiaki. / Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers. Silicon Science and Advanced Micro-Device Engineering I. 2011. pp. 51-56 (Key Engineering Materials).
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