TY - GEN
T1 - Thermosensitive micelles composed of poly(lactide)-G-poly(NIPAM-CO-HEMA) graft copolymers
AU - Quynh, Tran Minh
AU - Yoneyama, Masaru
AU - Maki, Yasuyuki
AU - Nagasawa, Naotsugu
AU - Dobashi, Toshiaki
PY - 2011/1/20
Y1 - 2011/1/20
N2 - Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.
AB - Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.
UR - http://www.scopus.com/inward/record.url?scp=78651430764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651430764&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.459.51
DO - 10.4028/www.scientific.net/KEM.459.51
M3 - Conference contribution
AN - SCOPUS:78651430764
SN - 9780878492176
T3 - Key Engineering Materials
SP - 51
EP - 56
BT - Silicon Science and Advanced Micro-Device Engineering I
T2 - 5th International Symposium on Silicon Science, ISSS 2009 and the 1st International Conference on Advanced Micro-Device Engineering, AMDE 2009
Y2 - 10 December 2009 through 11 December 2009
ER -