Thioredoxin and ventricular remodeling

Tetsuro Ago, Junichi Sadoshima

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Increasing bodies of evidence indicate that reactive oxygen species (ROS) produced by mitochondria and other sources play an essential role in mediating ventricular remodeling after myocardial infarction and the development of heart failure. Antioxidants scavenge ROS, thereby maintaining the reduced environment of cells and inhibiting ventricular remodeling in the heart. Thioredoxin not only functions as a major antioxidant in the heart but also interacts with important signaling molecules and transcription factors, thereby modulating various cellular functions. The activity of thioredoxin is regulated by a variety of mechanisms, such as transcription, localization, protein-protein interaction, and post-translational modification. In this review, we will summarize the cardiac effects of thioredoxin and the mechanisms by which thioredoxin mediates inhibition of ventricular remodeling.

Original languageEnglish
Pages (from-to)762-773
Number of pages12
JournalJournal of Molecular and Cellular Cardiology
Volume41
Issue number5
DOIs
Publication statusPublished - Nov 1 2006
Externally publishedYes

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Thioredoxins
Ventricular Remodeling
Reactive Oxygen Species
Antioxidants
Post Translational Protein Processing
Mitochondria
Transcription Factors
Heart Failure
Myocardial Infarction
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Thioredoxin and ventricular remodeling. / Ago, Tetsuro; Sadoshima, Junichi.

In: Journal of Molecular and Cellular Cardiology, Vol. 41, No. 5, 01.11.2006, p. 762-773.

Research output: Contribution to journalReview article

Ago, Tetsuro ; Sadoshima, Junichi. / Thioredoxin and ventricular remodeling. In: Journal of Molecular and Cellular Cardiology. 2006 ; Vol. 41, No. 5. pp. 762-773.
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