"Threading" of Β-sheet peptides via radical polymerization

Takeshi Mori, Shiro Yasutake, Hideki Inoue, Keiji Minagawa, Masami Tanaka, Takuro Niidome, Yoshiki Katayama

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    A nonamer peptide containing a diene group in the center of the sequence was synthesized. When the peptide forms an antiparallel β-sheet, the diene groups align ca. 5 Å apart on the β-sheet. The diene groups successfully photopolymerized without distorting the β-sheet structure. The obtained β-sheet showed high stability against acid denaturation and addition of 1,1,1,3,3,3-hexafluoroisopropanol.

    Original languageEnglish
    Pages (from-to)318-321
    Number of pages4
    JournalBiomacromolecules
    Volume8
    Issue number2
    DOIs
    Publication statusPublished - Feb 1 2007

    All Science Journal Classification (ASJC) codes

    • Bioengineering
    • Biomaterials
    • Polymers and Plastics
    • Materials Chemistry

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