Three-dimensional cell culture device utilizing thin membrane deformation by decompression

Takahisa Anada, Taisuke Masuda, Yoshitomo Honda, Junji Fukuda, Fumihito Arai, Toshio Fukuda, Osamu Suzuki

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

We have developed a novel multicellular aggregate (spheroid) culture device that utilizes thin polydimethylsiloxane membrane deformation by decompression. The device was capable of producing thousands of spheroids rapidly at a time and regulating the diameter of spheroids with narrow size distribution. The spheroids were easily retrieved from the device noninvasively. These characteristics of the device suggest that it has the potential for use in a wide variety of applications, such as drug screening and tissue engineering.

Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalSensors and Actuators, B: Chemical
Volume147
Issue number1
DOIs
Publication statusPublished - May 18 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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