Three-dimensional culture system of cancer cells combined with biomaterials for drug screening

Teruki Nii, Kimiko Makino, Yasuhiko Tabata

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Anticancer drug screening is one of the most important research and development processes to develop new drugs for cancer treatment. However, there is a problem resulting in gaps between the in vitro drug screening and preclinical or clinical study. This is mainly because the condition of cancer cell culture is quite different from that in vivo. As a trial to mimic the in vivo cancer environment, there has been some research on a three-dimensional (3D) culture system by making use of biomaterials. The 3D culture technologies enable us to give cancer cells an in vitro environment close to the in vivo condition. Cancer cells modified to replicate the in vivo cancer environment will promote the biological research or drug discovery of cancers. This review introduces the in vitro research of 3D cell culture systems with biomaterials in addition to a brief summary of the cancer environment.

Original languageEnglish
Article number2754
Pages (from-to)1-24
Number of pages24
JournalCancers
Volume12
Issue number10
DOIs
Publication statusPublished - Oct 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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