Three-dimensional visualization of intact mouse lung by synchrotron radiation CT

Toshihiro Sera, Naoto Yagi, Kentaro Uesugi

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

Airway is a complex branching structure of many compliant tubes, and then airway geometry and compliance have many biomechanical and clinical implications. In this study, we visualized an intact mouse lung without dehydration and fixation using synchrotron radiation CT at SPring-8 in Japan. The CT system consists of X-ray light source, a double crystal monochromator, a rotation stage and a high-resolution image detector. The angular projections were sequentially obtained during the sample rotation with the total scan shorter time than 15 min. The effective spatial resolution was 30 μm. Using this system, three-dimensional images of small airways and alveoli were obtained under physiological condition. Moreover, we visualized the same airways at FRC (functional residual capacity) and TLC (total lung capacity). The airway geometry deformed dramatically and the diameter expanded 1.2-1.7 times at TLC in comparison with at FRC. This deformation was larger for smaller airways. This system opens the way to new research of the pulmonary dynamics and physiological implications.

Original languageEnglish
Pages (from-to)1294-1297
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 II
Publication statusPublished - Dec 1 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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