Three-Year Prospective Follow-up of Potential Pediatric Candidate for Intestinal Transplantation

T. Ueno, M. Wada, K. Hoshino, Toshiharu Matsuura, S. Ida, H. Okuyama

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Intestinal transplantation (ITx) is a treatment for refractory intestinal failure (IF). However, the indications for and timing of ITx are still controversial because the course of IF is unknown. We performed a prospective multi-institutional cohort study to identify the prognostic factors for referral to an ITx facility. Patients under 18 years of age in Japan who suffered from IF and had received parenteral nutrition for longer than 6 months were enrolled in this study. They were followed up for 3 years. Seventy-two patients were followed. The mean age at the beginning of the study was 7.0 years. Diagnoses were short gut syndrome (n = 25), motility disorder (n = 45), and other (n = 2). The overall 3-year survival rate was 95%. The 3-year survival rate was 86% in patients with intestinal-failure-associated liver disease (IFALD) (n = 6) compared to 97% in those without IFALD (n = 66) (P =.0003). Furthermore, the 3-year survival rates of patients who did and did not meet the criteria for ITx were 82% (n = 11) and 97% (n = 62), respectively (P =.034). Six (44%) of 14 patients whose performance status (PS) was ≥3 at enrollment were dead or still had a PS ≥ 3 at 3 years. This study indicates that IFALD is a poor prognostic factor in pediatric patients with IF. Our indication for ITx, namely the presence of IFALD or loss of more than 2 parenteral nutrition access sites, seems to be applicable.

Original languageEnglish
Pages (from-to)2779-2782
Number of pages4
JournalTransplantation Proceedings
Volume50
Issue number9
DOIs
Publication statusPublished - Nov 1 2018

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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