Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding

T. N. Chau, Y. W. Chan, D. Patch, S. Tokunaga, L. Greenslade, A. K. Burroughs

Research output: Contribution to journalArticle

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Abstract

Background - Routine coagulation tests do not necessarily reflect haemostasis in vivo in cirrhotic patients, particularly those who have bleeding varices. Thrombelastography (TEG) can provide a global assessment of haemostatic function from initial clot formation to clot dissolution. Aim - To evaluate TEG changes in cirrhotic patients with variceal bleeding and their association with early rebleeding. Patients/Methods - Twenty cirrhotic patients with active variceal bleeding had serial TEG and routine coagulation tests daily for seven days. The TEG variables before the day of rebleeding (n = 6) were compared with those of patients without rebleeding (n = 14). Results - Baseline characteristics of the rebleeding and non-rebleeding groups were comparable apart from a higher incidence of uncontrolled infection on the day of rebleeding in the rebleeding group (p = 0.007). The patients in the rebleeding group were more hypocoagulable before the day of rebleeding as shown by longer r (42 v 24 mm, p < 0.001) and k (48 v 13 mm, p < 0.001) and smaller a (12 v 38°, p < 0.001) compared with the mean of daily results of the non-rebleeding group. Routine coagulation tests, however, showed no significant differences between the two groups. Conclusion - The results of serial TEG measurements suggest that hypocoagulability may be associated with early rebleeding in cirrhotic patients.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalGut
Volume43
Issue number2
DOIs
Publication statusPublished - Jan 1 1998

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Thrombelastography
Hemorrhage
Varicose Veins
Hemostatics
Hemostasis
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Chau, T. N., Chan, Y. W., Patch, D., Tokunaga, S., Greenslade, L., & Burroughs, A. K. (1998). Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. Gut, 43(2), 267-271. https://doi.org/10.1136/gut.43.2.267

Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. / Chau, T. N.; Chan, Y. W.; Patch, D.; Tokunaga, S.; Greenslade, L.; Burroughs, A. K.

In: Gut, Vol. 43, No. 2, 01.01.1998, p. 267-271.

Research output: Contribution to journalArticle

Chau, TN, Chan, YW, Patch, D, Tokunaga, S, Greenslade, L & Burroughs, AK 1998, 'Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding', Gut, vol. 43, no. 2, pp. 267-271. https://doi.org/10.1136/gut.43.2.267
Chau TN, Chan YW, Patch D, Tokunaga S, Greenslade L, Burroughs AK. Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. Gut. 1998 Jan 1;43(2):267-271. https://doi.org/10.1136/gut.43.2.267
Chau, T. N. ; Chan, Y. W. ; Patch, D. ; Tokunaga, S. ; Greenslade, L. ; Burroughs, A. K. / Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. In: Gut. 1998 ; Vol. 43, No. 2. pp. 267-271.
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