Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer

Ryosuke Taguchi; Kenji Tsuchihashi; Yuta Okumura; Michitaka Nakano; Tomoyasu Yoshihiro; Hirofumi Ohmura; Nobuhiro Tsuruta; Fumiyasu Hanamura; Kyoko Yamaguchi; Mamoru Ito; Hiroshi Ariyama; Hitoshi Kusaba; Koichi Akashi; Eishi Baba

doi:10.2169/internalmedicine.4785-20

Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer

Ryosuke Taguchi, Kenji Tsuchihashi, Yuta Okumura, Michitaka Nakano, Tomoyasu Yoshihiro, Hirofumi Ohmura, Nobuhiro Tsuruta, Fumiyasu Hanamura, Kyoko Yamaguchi, Mamoru Ito, Hiroshi Ariyama, Hitoshi Kusaba, Koichi Akashi, Eishi Baba

Research output: Contribution to journal › Article › peer-review

Abstract

Drug-induced immune thrombocytopenia (DITP) is an important cause of thrombocytopenia. A 73-year-old man with relapsed rectal carcinoma received S-1, oxaliplatin and bevacizumab combination therapy (SOX+ Bev). Dexamethasone was administered as an antiemetic prophylaxis. On day 2 of the first cycle, thrombocytopenia (8,000/μL) was observed. We sequentially omitted any drugs suspected to possibly induce thrombocytopenia and confirmed dexamethasone as the cause of thrombocytopenia. DITP induced by synthetic corticosteroids is very rare and this is the first case report of DITP induced by dexamethasone. Although rare, DITP due to synthetic corticosteroids including dexamethasone should be a differential diagnosis among patients receiving synthetic corticosteroids with thrombocytopenia.

Original language	English
Pages (from-to)	2571-2575
Number of pages	5
Journal	Internal Medicine
Volume	59
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.4785-20
Publication status	Published - Oct 15 2020

All Science Journal Classification (ASJC) codes

Internal Medicine

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Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer. / Taguchi, Ryosuke; Tsuchihashi, Kenji ; Okumura, Yuta; Nakano, Michitaka; Yoshihiro, Tomoyasu; Ohmura, Hirofumi; Tsuruta, Nobuhiro; Hanamura, Fumiyasu; Yamaguchi, Kyoko; Ito, Mamoru; Ariyama, Hiroshi ; Kusaba, Hitoshi ; Akashi, Koichi ; Baba, Eishi.

In: Internal Medicine, Vol. 59, No. 20, 15.10.2020, p. 2571-2575.

Research output: Contribution to journal › Article › peer-review

Taguchi, Ryosuke ; Tsuchihashi, Kenji ; Okumura, Yuta ; Nakano, Michitaka ; Yoshihiro, Tomoyasu ; Ohmura, Hirofumi ; Tsuruta, Nobuhiro ; Hanamura, Fumiyasu ; Yamaguchi, Kyoko ; Ito, Mamoru ; Ariyama, Hiroshi ; Kusaba, Hitoshi ; Akashi, Koichi ; Baba, Eishi. / Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer. In: Internal Medicine. 2020 ; Vol. 59, No. 20. pp. 2571-2575.

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title = "Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer",

abstract = "Drug-induced immune thrombocytopenia (DITP) is an important cause of thrombocytopenia. A 73-year-old man with relapsed rectal carcinoma received S-1, oxaliplatin and bevacizumab combination therapy (SOX+ Bev). Dexamethasone was administered as an antiemetic prophylaxis. On day 2 of the first cycle, thrombocytopenia (8,000/μL) was observed. We sequentially omitted any drugs suspected to possibly induce thrombocytopenia and confirmed dexamethasone as the cause of thrombocytopenia. DITP induced by synthetic corticosteroids is very rare and this is the first case report of DITP induced by dexamethasone. Although rare, DITP due to synthetic corticosteroids including dexamethasone should be a differential diagnosis among patients receiving synthetic corticosteroids with thrombocytopenia.",

author = "Ryosuke Taguchi and Kenji Tsuchihashi and Yuta Okumura and Michitaka Nakano and Tomoyasu Yoshihiro and Hirofumi Ohmura and Nobuhiro Tsuruta and Fumiyasu Hanamura and Kyoko Yamaguchi and Mamoru Ito and Hiroshi Ariyama and Hitoshi Kusaba and Koichi Akashi and Eishi Baba",

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AU - Nakano, Michitaka

AU - Yoshihiro, Tomoyasu

AU - Ohmura, Hirofumi

AU - Tsuruta, Nobuhiro

AU - Hanamura, Fumiyasu

AU - Yamaguchi, Kyoko

AU - Ito, Mamoru

AU - Ariyama, Hiroshi

AU - Kusaba, Hitoshi

AU - Akashi, Koichi

AU - Baba, Eishi

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AB - Drug-induced immune thrombocytopenia (DITP) is an important cause of thrombocytopenia. A 73-year-old man with relapsed rectal carcinoma received S-1, oxaliplatin and bevacizumab combination therapy (SOX+ Bev). Dexamethasone was administered as an antiemetic prophylaxis. On day 2 of the first cycle, thrombocytopenia (8,000/μL) was observed. We sequentially omitted any drugs suspected to possibly induce thrombocytopenia and confirmed dexamethasone as the cause of thrombocytopenia. DITP induced by synthetic corticosteroids is very rare and this is the first case report of DITP induced by dexamethasone. Although rare, DITP due to synthetic corticosteroids including dexamethasone should be a differential diagnosis among patients receiving synthetic corticosteroids with thrombocytopenia.

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Thrombocytopenia caused by dexamethasone in a patient with colorectal cancer

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