Thymidine phosphorylase activity and angiogenesis in gastric cancer.

Y. Kakeji; Yoshihiko Maehara; M. Tomoda; Akira Kabashima; S. Oda; T. Ooshiro; H. Baba; S. Kohnoe; K. Sugimachi

Thymidine phosphorylase activity and angiogenesis in gastric cancer.

Y. Kakeji, Yoshihiko Maehara, M. Tomoda, Akira Kabashima, S. Oda, T. Ooshiro, H. Baba, S. Kohnoe, K. Sugimachi

Research output: Contribution to journal › Article › peer-review

Abstract

Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.

Original language	English
Pages (from-to)	995-999
Number of pages	5
Journal	Oncology reports
Volume	6
Issue number	5
Publication status	Published - Jan 1 1999

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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T1 - Thymidine phosphorylase activity and angiogenesis in gastric cancer.

AU - Kakeji, Y.

AU - Maehara, Yoshihiko

AU - Tomoda, M.

AU - Kabashima, Akira

AU - Oda, S.

AU - Ooshiro, T.

AU - Baba, H.

AU - Kohnoe, S.

AU - Sugimachi, K.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.

AB - Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.

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