Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma

Ryuji Yasumatsu; Torahiko Nakashima; Moriyasu Yamauchi; Takahiro Wakasaki; Muneyuki Masuda; Shizuo Komune

doi:10.1016/j.anl.2010.07.011

Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma

Ryuji Yasumatsu, Torahiko Nakashima, Moriyasu Yamauchi, Takahiro Wakasaki, Muneyuki Masuda, Shizuo Komune

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The aim of this study was to evaluate the immunohistochemical TS expression in patients with maxillary sinus SCC. Methods The value of immunohistochemical TS expression as a predictive indicator for 5-FU efficacy was retrospectively examined in 47 patients with maxillary sinus SCC. Results Of the 47 patients, 29 (62%) showed complete response for 5-FU based chemoradiotherapy. Seventeen of 19 (89%) TS low cases showed a complete response, whereas 12 of 28 (43%) TS high cases showed complete response for 5-FU based chemoradiotherapy. Low TS patients had significantly better response rates compared with high TS patients. Conclusion These findings suggest that TS expression affects the chemotherapeutic effect of 5-FU in patients with maxillary sinus SCC and the assessment of TS expression level might be useful both in the management and in the treatment of maxillary sinus SCC.

Original language	English
Pages (from-to)	387-391
Number of pages	5
Journal	Auris Nasus Larynx
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.anl.2010.07.011
Publication status	Published - Jun 2011

All Science Journal Classification (ASJC) codes

Surgery
Otorhinolaryngology

Access to Document

10.1016/j.anl.2010.07.011

Cite this

@article{eda4074a3cd147ed8d0ade8c01f16289,

title = "Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma",

abstract = "Objective: The aim of this study was to evaluate the immunohistochemical TS expression in patients with maxillary sinus SCC. Methods The value of immunohistochemical TS expression as a predictive indicator for 5-FU efficacy was retrospectively examined in 47 patients with maxillary sinus SCC. Results Of the 47 patients, 29 (62%) showed complete response for 5-FU based chemoradiotherapy. Seventeen of 19 (89%) TS low cases showed a complete response, whereas 12 of 28 (43%) TS high cases showed complete response for 5-FU based chemoradiotherapy. Low TS patients had significantly better response rates compared with high TS patients. Conclusion These findings suggest that TS expression affects the chemotherapeutic effect of 5-FU in patients with maxillary sinus SCC and the assessment of TS expression level might be useful both in the management and in the treatment of maxillary sinus SCC.",

author = "Ryuji Yasumatsu and Torahiko Nakashima and Moriyasu Yamauchi and Takahiro Wakasaki and Muneyuki Masuda and Shizuo Komune",

year = "2011",

month = jun,

doi = "10.1016/j.anl.2010.07.011",

language = "English",

volume = "38",

pages = "387--391",

journal = "Auris Nasus Larynx",

issn = "0385-8146",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma

AU - Yasumatsu, Ryuji

AU - Nakashima, Torahiko

AU - Yamauchi, Moriyasu

AU - Wakasaki, Takahiro

AU - Masuda, Muneyuki

AU - Komune, Shizuo

PY - 2011/6

Y1 - 2011/6

N2 - Objective: The aim of this study was to evaluate the immunohistochemical TS expression in patients with maxillary sinus SCC. Methods The value of immunohistochemical TS expression as a predictive indicator for 5-FU efficacy was retrospectively examined in 47 patients with maxillary sinus SCC. Results Of the 47 patients, 29 (62%) showed complete response for 5-FU based chemoradiotherapy. Seventeen of 19 (89%) TS low cases showed a complete response, whereas 12 of 28 (43%) TS high cases showed complete response for 5-FU based chemoradiotherapy. Low TS patients had significantly better response rates compared with high TS patients. Conclusion These findings suggest that TS expression affects the chemotherapeutic effect of 5-FU in patients with maxillary sinus SCC and the assessment of TS expression level might be useful both in the management and in the treatment of maxillary sinus SCC.

AB - Objective: The aim of this study was to evaluate the immunohistochemical TS expression in patients with maxillary sinus SCC. Methods The value of immunohistochemical TS expression as a predictive indicator for 5-FU efficacy was retrospectively examined in 47 patients with maxillary sinus SCC. Results Of the 47 patients, 29 (62%) showed complete response for 5-FU based chemoradiotherapy. Seventeen of 19 (89%) TS low cases showed a complete response, whereas 12 of 28 (43%) TS high cases showed complete response for 5-FU based chemoradiotherapy. Low TS patients had significantly better response rates compared with high TS patients. Conclusion These findings suggest that TS expression affects the chemotherapeutic effect of 5-FU in patients with maxillary sinus SCC and the assessment of TS expression level might be useful both in the management and in the treatment of maxillary sinus SCC.

UR - http://www.scopus.com/inward/record.url?scp=79952735486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952735486&partnerID=8YFLogxK

U2 - 10.1016/j.anl.2010.07.011

DO - 10.1016/j.anl.2010.07.011

M3 - Article

C2 - 21035287

AN - SCOPUS:79952735486

SN - 0385-8146

VL - 38

SP - 387

EP - 391

JO - Auris Nasus Larynx

JF - Auris Nasus Larynx

IS - 3

ER -

Thymidylate synthase expression as a predictor of clinical response to 5-fluorouracil-based chemoradiotherapy in patients with maxillary sinus squamous cell carcinoma

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this