Abstract
After administration of indomethacin, an inhibitor of prostaglandin synthesis, the number of splenic T cells increased in normal mice but not in adult-thymectomized or athymic nude mice. The enlarged T-cell population consisted mainly of Lyt-1+2+ cells. This thymus-dependent increase in T-cell population augmented in vivo antibody response to sheep erythrocytes, a T-dependent antigen. The increased T-cell population also included suppressor cells that were eliminated by treatment with anti-Lyt-2 antibody plus complement. These results suggest that increased T cells in the spleen were recruited from the thymus by an indomethacin-mediated mechanism and participated in immune responses as regulator cells.
Original language | English |
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Pages (from-to) | 43-51 |
Number of pages | 9 |
Journal | Cellular Immunology |
Volume | 75 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1983 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology