Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation

K. Honda, H. Takada, Y. Nagatoshi, K. Akazawa, S. Ohga, E. Ishii, J. Okamura, T. Hara

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The contribution of the thymus-dependent pathway and thymus-independent pathways for T cell regeneration after BMT in children is still unclear. We analyzed the kinetics of T cell regenerative pathways after allogeneic BMT. The number of CD4+CD45RA+ T cells, a thymus-dependent population, was very low until 3 months after BMT. The numbers of CD28- T cells and CD8+ T cells expressing CD8α/α homodimer (CD8α/α+ T cells), a thymus-independent population, increased shortly after BMT, beyond the levels of healthy children in some patients. The numbers of Vγ9+Vδ2+ and Vα24+ T cells, which represent populations of extrathymic development, were less than 200/μl during the 6 months after BMT. There was a significant inverse correlation between the percentages of CD4+CD45RA+ and CD28- T-cells at 1 month, and a positive correlation between the percentages of CD28- and CD8α/α+ T cells at 2 and 3 months after BMT. The mean age at BMT was higher in patients with a high level of CD8α/α+ T cells than in those without an increase in these cells, suggesting the influence of thymic function on the regenerative pathways. These results suggest that the thymus-independent pathway is the dominant source of T cells even in children shortly after allogeneic BMT.

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalBone Marrow Transplantation
Volume25
Issue number6
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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