Thyroid evaluation in patients with primary hyperparathyroidism

Toshihiro Masatsugu, Hiroyuki Yamashita, Shiro Noguchi, Ryuichi Nishii, Yutaka Koga, Shin Watanabe, Shinya Uchino, Hiroto Yamashita, Akira Ohshima, Syoji Kuroki, Masao Tanaka

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We evaluated the efficacy of preoperative high-resolution ultrasonography (US) for diagnosing possible concomitant thyroid disease which affects the surgical management in patients with primary hyperparathyroidism (pHPT). One hundred and nine patients with sporadic pHPT underwent US with or without ultrasound-guided fine-needle aspiration biopsy (US-FNAB). Diagnosis of concomitant thyroid nodules by US and US-FNAB were compared with the histopathological findings. Of the 109 patients, 19 (17.4%) had malignant thyroid nodules, 26 (23.9%) had benign thyroid nodules alone, and 12 (11.0%) had diffuse goiter. The sensitivity, specificity, and accuracy of diagnosing 72 thyroid nodules were 91.3%, 91.8%, and 91.7% for US, 57.9%, 94.3%, and 81.5% for US-FNAB, and 95.7%, 91.8%, and 93.1% for combined US and US-FNAB, respectively. True positive/false negative ratio of US-FNAB diagnosis was significantly lower in nodules of 5-9 mm than nodules of 10 mm or more. Four unexpected thyroid cancers existed at a different site in 3 of the 39 patients with palpable thyroid disease. Five thyroid cancers were histopathologically confirmed in 5 (7.1%) of 70 patients without palpable thyroid disease. Eight (88.9%) of the 9 non-palpable thyroid cancers were accurately diagnosed by combined US and US-FNAB. Preoperative US is useful for evaluation of possible concomitant thyroid disease, especially for prediction of malignancy.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalEndocrine Journal
Volume52
Issue number2
DOIs
Publication statusPublished - Apr 2005

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Thyroid evaluation in patients with primary hyperparathyroidism'. Together they form a unique fingerprint.

  • Cite this

    Masatsugu, T., Yamashita, H., Noguchi, S., Nishii, R., Koga, Y., Watanabe, S., Uchino, S., Yamashita, H., Ohshima, A., Kuroki, S., & Tanaka, M. (2005). Thyroid evaluation in patients with primary hyperparathyroidism. Endocrine Journal, 52(2), 177-182. https://doi.org/10.1507/endocrj.52.177