Thyroid Hormone in the CNS: Contribution of Neuron–Glia Interaction

Mami Noda

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)


The endocrine system and the central nervous system (CNS) are intimately linked. Among hormones closely related to the nervous system, thyroid hormones (THs) are critical for the regulation of development and differentiation of neurons and neuroglia and hence for development and function of the CNS. T3 (3,3′,5-triiodothyronine), an active form of TH, is important not only for neuronal development but also for differentiation of astrocytes and oligodendrocytes, and for microglial development. In adult brain, T3 affects glial morphology with sex- and age-dependent manner and therefore may affect their function, leading to influence on neuron–glia interaction. T3 is an important signaling factor that affects microglial functions such as migration and phagocytosis via complex mechanisms. Therefore, dysfunction of THs may impair glial function as well as neuronal function and thus disturb the brain, which may cause mental disorders. Investigations on molecular and cellular basis of hyperthyroidism and hypothyroidism will help us to understand changes in neuron–glia interaction and therefore consequent psychiatric symptoms.

Original languageEnglish
Title of host publicationThyroid Hormone
EditorsGerald Litwack
PublisherAcademic Press Inc.
Number of pages19
ISBN (Print)9780128141168
Publication statusPublished - Jan 1 2018

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology


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