Thyrotropin-releasing hormone increased heat production without the involvement of corticotropin-releasing factor in neonatal chicks

Tetsuya Tachibana, Hirokazu Takahashi, Daichi Oikawa, D. Michael Denbow, Mitsuhiro Furuse

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13 Citations (Scopus)

Abstract

Thyrotropin-releasing hormone (TRH) is a hypothalamic signal in the hypothalamic-pituitary-thyroid (HPT) axis, and is well known as a hyperthermic hormone in the brain of chicks. The thermogenetic effect leads to the hypothesis that central TRH increases heat production (HP) in chicks. The purpose of the present study was to clarify whether central TRH affects HP of neonatal chicks, and if such an effect is mediated by corticotropin-releasing factor (CRF) since the thermogenetic effect of TRH is mediated by CRF. Intracerebroventricular (ICV) injection of TRH (14 and 55 nmol) dose-dependently increased oxygen consumption, carbon dioxide production and HP, and a similar effect was also observed with CRF (2.1 and 21 pmol). The TRH-induced increase in HP could not be attenuated by astressin, a CRF receptor antagonist, while the effect of CRF was completely diminished by astressin. The present study demonstrates that central TRH increases HP in chicks but the effect was not related to CRF.

Original languageEnglish
Pages (from-to)528-532
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume83
Issue number4
DOIs
Publication statusPublished - Apr 1 2006

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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