Time course of changes in maternal left ventricular function during subsequent pregnancy in women with a history of gestational hypertensive disorders

Michinari Hieda, Jeung Ki Yoo, Dan Dan Sun, Yoshiyuki Okada, Rosemary S. Parker, Monique A. Roberts-Reeves, Beverley Adams-Huet, David B. Nelson, Benjamin D. Levine, Qi Fu

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Women with a history of gestational hypertensive disorders (GHD) are at increased risk for developing perinatal cardiovascular complications (e.g., gestational hypertension, preeclampsia, etc.) in subsequent pregnancies. The underlying mechanisms remain uncertain, but impaired maternal left ventricular function may be one contributing factor for these complications. We evaluated the time course of changes in left ventricular function before, during, and after pregnancy in women with prior GHD. Sixteen women with a history of GHD (the high-risk group) and 25 women without such a history (controls) were enrolled. Resting hemodynamic and echocardiographic measurements were longitudinally performed before pregnancy, during early pregnancy (4–8 wk of gestation), during late pregnancy (32–36 wk of gestation), and postpartum (6–10 wk after delivery). Pregnancy outcomes were obtained after delivery. At prepregnancy, there was no difference in blood pressure and heart rate between the groups. Corrected isovolumic relaxation time was longer, E/e= was larger, and Tei index was greater in the high-risk group than controls. Moreover, the rate of GHD during the study was significantly greater in the high-risk group than controls [odds ratio = 8.94 (95% confidence interval: 1.55–51.5), P = 0.007]. Multiple logistic regression analysis adjusted for age demonstrated that prepregnancy E/e= was an independent predictor for GHD (P = 0.017). Thus, women with a history of GHD have modestly impaired cardiac function prepregnancy compared with controls, which identifies an increased susceptibility to developing cardiovascular complications during a subsequent pregnancy.

Original languageEnglish
Pages (from-to)R587-R594
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number4
Publication statusPublished - Oct 2018
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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