Time-dependent changes in the plasma amino acid concentration in diabetes mellitus

Taiga Mochida, Takayuki Tanaka, Yasuko Shiraki, Hiroko Tajiri, Shirou Matsumoto, Kazutaka Shimbo, Toshihiko Ando, Kimitoshi Nakamura, Masahiro Okamoto, Fumio Endo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalMolecular Genetics and Metabolism
Volume103
Issue number4
DOIs
Publication statusPublished - Aug 1 2011

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Medical problems
Type 1 Diabetes Mellitus
Diabetes Mellitus
Plasmas
Amino Acids
Branched Chain Amino Acids
Citrulline
Isoleucine
Valine
Proline
Leucine
Alanine
Insulin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

Cite this

Mochida, T., Tanaka, T., Shiraki, Y., Tajiri, H., Matsumoto, S., Shimbo, K., ... Endo, F. (2011). Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. Molecular Genetics and Metabolism, 103(4), 406-409. https://doi.org/10.1016/j.ymgme.2011.05.002

Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. / Mochida, Taiga; Tanaka, Takayuki; Shiraki, Yasuko; Tajiri, Hiroko; Matsumoto, Shirou; Shimbo, Kazutaka; Ando, Toshihiko; Nakamura, Kimitoshi; Okamoto, Masahiro; Endo, Fumio.

In: Molecular Genetics and Metabolism, Vol. 103, No. 4, 01.08.2011, p. 406-409.

Research output: Contribution to journalArticle

Mochida, T, Tanaka, T, Shiraki, Y, Tajiri, H, Matsumoto, S, Shimbo, K, Ando, T, Nakamura, K, Okamoto, M & Endo, F 2011, 'Time-dependent changes in the plasma amino acid concentration in diabetes mellitus', Molecular Genetics and Metabolism, vol. 103, no. 4, pp. 406-409. https://doi.org/10.1016/j.ymgme.2011.05.002
Mochida, Taiga ; Tanaka, Takayuki ; Shiraki, Yasuko ; Tajiri, Hiroko ; Matsumoto, Shirou ; Shimbo, Kazutaka ; Ando, Toshihiko ; Nakamura, Kimitoshi ; Okamoto, Masahiro ; Endo, Fumio. / Time-dependent changes in the plasma amino acid concentration in diabetes mellitus. In: Molecular Genetics and Metabolism. 2011 ; Vol. 103, No. 4. pp. 406-409.
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