TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Saša Novak, John William Richard Druce, Qi Zhi Chen, Aldo R. Boccaccini

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass® layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass® particles was shown to impart the rutile TiO2 scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.

Original languageEnglish
Pages (from-to)1442-1448
Number of pages7
JournalJournal of Materials Science
Volume44
Issue number6
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

Tissue Scaffolds
Bioactive glass
Lactic acid
Scaffolds (biology)
Tissue engineering
Foams
Bone
Coatings
Composite coatings
Body fluids
Structural integrity
Durapatite
Bioactivity
Hydroxyapatite
Scaffolds
Compressive strength
Pore size
Compaction
Porosity
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds. / Novak, Saša; Druce, John William Richard; Chen, Qi Zhi; Boccaccini, Aldo R.

In: Journal of Materials Science, Vol. 44, No. 6, 01.03.2009, p. 1442-1448.

Research output: Contribution to journalArticle

Novak, Saša ; Druce, John William Richard ; Chen, Qi Zhi ; Boccaccini, Aldo R. / TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds. In: Journal of Materials Science. 2009 ; Vol. 44, No. 6. pp. 1442-1448.
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