TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

Saša Novak, John William Richard Druce, Qi Zhi Chen, Aldo R. Boccaccini

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)

    Abstract

    TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass® layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass® particles was shown to impart the rutile TiO2 scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.

    Original languageEnglish
    Pages (from-to)1442-1448
    Number of pages7
    JournalJournal of Materials Science
    Volume44
    Issue number6
    DOIs
    Publication statusPublished - Mar 1 2009

    All Science Journal Classification (ASJC) codes

    • Materials Science(all)
    • Mechanics of Materials
    • Mechanical Engineering

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