Tissue culture on a chip: Developmental biology applications of self-organized capillary networks in microfluidic devices

Takashi Miura, Ryuji Yokokawa

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Organ culture systems are used to elucidate the mechanisms of pattern formation in developmental biology. Various organ culture techniques have been used, but the lack of microcirculation in such cultures impedes the long-term maintenance of larger tissues. Recent advances in microfluidic devices now enable us to utilize self-organized perfusable capillary networks in organ cultures. In this review, we will overview past approaches to organ culture and current technical advances in microfluidic devices, and discuss possible applications of microfluidics towards the study of developmental biology.

Original languageEnglish
Pages (from-to)505-515
Number of pages11
JournalDevelopment Growth and Differentiation
Volume58
Issue number6
DOIs
Publication statusPublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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