Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer

Tetsuya Kusumoto, Yoshihiko Maehara, Yoshihisa Sakaguchi, Yoshihiro Kakeji, Takayuki Nohzuka, Motonosuke Furusawa, Keizo Sugimachi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalOncology (Switzerland)
Volume50
Issue number4
DOIs
Publication statusPublished - Jan 1 1993

Fingerprint

Tissue Distribution
Platinum
Cisplatin
Stomach Neoplasms
Atomic Spectrophotometry
Liver
Autopsy
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer. / Kusumoto, Tetsuya; Maehara, Yoshihiko; Sakaguchi, Yoshihisa; Kakeji, Yoshihiro; Nohzuka, Takayuki; Furusawa, Motonosuke; Sugimachi, Keizo.

In: Oncology (Switzerland), Vol. 50, No. 4, 01.01.1993, p. 214-217.

Research output: Contribution to journalArticle

Kusumoto, T, Maehara, Y, Sakaguchi, Y, Kakeji, Y, Nohzuka, T, Furusawa, M & Sugimachi, K 1993, 'Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer', Oncology (Switzerland), vol. 50, no. 4, pp. 214-217. https://doi.org/10.1159/000227181
Kusumoto, Tetsuya ; Maehara, Yoshihiko ; Sakaguchi, Yoshihisa ; Kakeji, Yoshihiro ; Nohzuka, Takayuki ; Furusawa, Motonosuke ; Sugimachi, Keizo. / Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer. In: Oncology (Switzerland). 1993 ; Vol. 50, No. 4. pp. 214-217.
@article{ee6a95b1bf764b6fa0dfc49841233eaf,
title = "Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer",
abstract = "Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.",
author = "Tetsuya Kusumoto and Yoshihiko Maehara and Yoshihisa Sakaguchi and Yoshihiro Kakeji and Takayuki Nohzuka and Motonosuke Furusawa and Keizo Sugimachi",
year = "1993",
month = "1",
day = "1",
doi = "10.1159/000227181",
language = "English",
volume = "50",
pages = "214--217",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Tissue distribution of cis- Diamminedichloroplatinum(II) following intraperitoneal administration to patients with recurrent gastric cancer

AU - Kusumoto, Tetsuya

AU - Maehara, Yoshihiko

AU - Sakaguchi, Yoshihisa

AU - Kakeji, Yoshihiro

AU - Nohzuka, Takayuki

AU - Furusawa, Motonosuke

AU - Sugimachi, Keizo

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.

AB - Using atomic absorption spectrophotometry, we determined the concentration of platinum in tissues obtained at autopsy of 4 patients with recurrent gastric cancer. Patients had been given intraperitoneal cis-diamminedichloro- platinum(II) (cisplatin, CDDP). There was no correlation between the con-centration of platinum and the dose of CDDP. Platinum was distributed in all organs examined, the highest amount being in the liver. Thus, when CDDP is administered intraperitoneally for treatment of patients with malignant disease, the toxicity to various organs, including the liver and the kidney, needs to be considered.

UR - http://www.scopus.com/inward/record.url?scp=0027273360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027273360&partnerID=8YFLogxK

U2 - 10.1159/000227181

DO - 10.1159/000227181

M3 - Article

C2 - 8497372

AN - SCOPUS:0027273360

VL - 50

SP - 214

EP - 217

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 4

ER -