Tissue-response to calcium-bonded titanium surface

Lei Zhang, Yasunori Ayukawa, Racquel Z. LeGeros, Shigeki Matsuya, Kiyoshi Koyano, Kunio Ishikawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our previous study demonstrated that calcium-bonded titanium surface (Ca-Ti) can be obtained by hydrothermal reaction between titanium(Ti) and CaCl2 and that bone-apatite like formation was observed after immersion in simulated body fluid. The purpose of the study was to determine the in vivo response to Ca-Ti surface using a rodent tibia model. Cylinders of commercially pure Ti were divided into three groups: (1) untreated group; (2) NaOH+hTi group: soaked in 5 mol/L NaOH solution at 60°C then heated at 400°C for 1 h; and (3) Ca-Ti group: hydrothermally treated in the presence of 10 mmol/L CaCl2 at 200°C for 24 h. The cylinders implanted in surgically created defects in tibias of 8-week old male Wistar rats were retrieved after 1, 2, and 4 weeks. Histomorphometric evaluations were made on stained decalcified thin sections. Results showed that at 1, 2, and 4 week after implantation, respectively, bone contact was 55.2 ± 16.4%, 88.1 ± 9.9%, and 96.1 ± 4.8% for Ca-Ti implants, 5.7 ± 5.3%, 19.9 ± 1.2%, 57.4 ± 4.8% for untreated; and 27.2 ± 0.7%, 70.9 ± 7.7%, and 96.0 ± 5.1% for NaOH+hTi implants. These results suggest that hydrothermal treatment with CaCl2 provides a bioactive Ca-Ti bonded surface that allows bone formation greater than that obtained with NaOH+heat treated Ti surfaces.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume95
Issue number1
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Titanium
Calcium
Tissue
Bone
Tibia
Bone and Bones
Apatites
Body fluids
Apatite
Body Fluids
Immersion
Osteogenesis
Wistar Rats
Rats
Rodentia
Hot Temperature
Defects

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys
  • Medicine(all)

Cite this

Tissue-response to calcium-bonded titanium surface. / Zhang, Lei; Ayukawa, Yasunori; LeGeros, Racquel Z.; Matsuya, Shigeki; Koyano, Kiyoshi; Ishikawa, Kunio.

In: Journal of Biomedical Materials Research - Part A, Vol. 95, No. 1, 10.2010, p. 33-39.

Research output: Contribution to journalArticle

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