Tissue-specific distribution of genistein, daidzein and bisphenol A in male Sprague-Dawley rats after intragastric administration

Shin Yasuda, Po Sheng Wu, Masaaki Okabe, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalReview article

Abstract

A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at Oh and levels subsequently dropped and then increased again, reaching the initial level at 24 h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24 h. Bisphenol A and equol in the MLN was detectable at 6 to 24 h and 24 h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6 h. Bisphenol A was detected in the epididymis at 6 to 12 h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalFood Science and Technology Research
Volume11
Issue number2
DOIs
Publication statusPublished - May 1 2005

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

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