Abstract
A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at Oh and levels subsequently dropped and then increased again, reaching the initial level at 24 h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24 h. Bisphenol A and equol in the MLN was detectable at 6 to 24 h and 24 h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6 h. Bisphenol A was detected in the epididymis at 6 to 12 h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 187-193 |
| Number of pages | 7 |
| Journal | Food Science and Technology Research |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - May 1 2005 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Chemical Engineering(all)
- Industrial and Manufacturing Engineering
- Marketing
Cite this
Tissue-specific distribution of genistein, daidzein and bisphenol A in male Sprague-Dawley rats after intragastric administration. / Yasuda, Shin; Wu, Po Sheng; Okabe, Masaaki; Tachibana, Hirofumi; Yamada, Koji.
In: Food Science and Technology Research, Vol. 11, No. 2, 01.05.2005, p. 187-193.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tissue-specific distribution of genistein, daidzein and bisphenol A in male Sprague-Dawley rats after intragastric administration
AU - Yasuda, Shin
AU - Wu, Po Sheng
AU - Okabe, Masaaki
AU - Tachibana, Hirofumi
AU - Yamada, Koji
PY - 2005/5/1
Y1 - 2005/5/1
N2 - A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at Oh and levels subsequently dropped and then increased again, reaching the initial level at 24 h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24 h. Bisphenol A and equol in the MLN was detectable at 6 to 24 h and 24 h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6 h. Bisphenol A was detected in the epididymis at 6 to 12 h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.
AB - A mixture of genistein, daidzein and bisphenol A was intragastrically given to male Sprague-Dawley rats. The tissue distribution of these compounds and equol, a metabolite of daidzein, was examined by high-performance liquid chromatography after administration. In the serum, liver and kidney, genistein, daidzein and bisphenol A were clearly detected at 6 to 24h. Equol was detected at Oh and levels subsequently dropped and then increased again, reaching the initial level at 24 h. In the mesenteric lymph node (MLN), thymus and spleen, genistein and daidzein were detected at 6 to 24 h. Bisphenol A and equol in the MLN was detectable at 6 to 24 h and 24 h, respectively. In the testicle, epididymis, spermatheca and prostate, higher levels of genistein and daidzein were detected around 6 h. Bisphenol A was detected in the epididymis at 6 to 12 h. These results suggest that the distribution of these chemicals and their tissue affinities in rats vary from tissue to tissue.
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UR - http://www.scopus.com/inward/citedby.url?scp=37849185073&partnerID=8YFLogxK
U2 - 10.3136/fstr.11.187
DO - 10.3136/fstr.11.187
M3 - Review article
AN - SCOPUS:37849185073
VL - 11
SP - 187
EP - 193
JO - Food Science and Technology Research
JF - Food Science and Technology Research
SN - 1344-6606
IS - 2
ER -