Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1

Seicho Makihira, Takahiro Shuto, Hiroki Nikawa, Keishi Okamoto, Yuichi Mine, Yuko Takamoto, Masaru Ohara, Koichiro Tsuji

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.

Original languageEnglish
Pages (from-to)1458-1470
Number of pages13
JournalInternational journal of molecular sciences
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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