TM4SF1 as a prognostic marker of pancreatic ductal adenocarcinoma is involved in migration and invasion of cancer cells

Biao Zheng, Kenoki Ohuchida, Lin Cui, Ming Zhao, Koji Shindo, Kenji Fujiwara, Tatsuya Manabe, Nobuhiro Torata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Shunichi Takahata, Kazuhiro Mizumoto, Yoshinao Oda, Masao Tanaka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The cell surface protein Transmembrane 4 L6 family member 1 (TM4SF1) has been detected in various tumors, and its expression on tumor cells is implicated in cancer cell metastasis and patient prognosis. The role of TM4SF1 in malignant tumors remains poorly understood, particularly in pancreatic cancer. We performed immunohistochemical staining to analyze the expression of TM4SF1 in resected pancreatic tissues and investigated the correlation between TM4SF1 expression and prognosis. The function of TM4SF1 in the invasion and migration of pancreatic cancer cells was analyzed in vitro using an RNA interference technique. In pancreatic cancer tissues, TM4SF1 expression was detected in cancer cells, and patients with high tumor levels of TM4SF1 showed longer survival times than those with low TM4SF1 levels (P=0.0332). In vitro, reduced TM4SF1 expression enhanced the migration (P<0.05) and invasion (P<0.05) of pancreatic cancer cells partially via decreased E-cadherin expression. TM4SF1 protein levels were also reduced after TGF-β1-induced epithelial-mesenchymal transition (EMT). TM4SF1 expression is associated with better prognosis in pancreatic cancer. Loss of TM4SF1 contributes to the invasion and migration of pancreatic cancer cells.

Original languageEnglish
Pages (from-to)490-498
Number of pages9
JournalInternational journal of oncology
Volume47
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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