Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli

Vongsavanh Phongsisay, Hiromitsu Hara, Shuji Fujimoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Campylobacter jejuni causes gastroenteritis and autoimmune neuropathy Guillain-Barré syndrome. The mechanism by which C. jejuni infection results in such the hyperimmunity is not completely understood. Host immunity plays an important role in the disease pathogenesis; however, little is known how immune system recognizes this human pathogen. In this study, we report that Toll-like receptors recognize distinct proteinase K-resistant glycoconjugates in C. jejuni and Escherichia coli. Lipopolysaccharide is solely proteinase-resistant glycoconjugate in E. coli. In contrast, C. jejuni possesses at least five different components that are resistant to proteinase digestion and are capable of inducing NF-κB activation through TLR2 and TLR4. Possession of multiple activators of Toll-like receptors may be the unique strategy of C. jejuni to trigger hyperimmunity.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalMolecular Immunology
Volume64
Issue number1
DOIs
Publication statusPublished - Mar 1 2015

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Campylobacter coli
Campylobacter jejuni
Glycoconjugates
Toll-Like Receptors
Peptide Hydrolases
Escherichia coli
Campylobacter Infections
Endopeptidase K
Gastroenteritis
Lipopolysaccharides
Digestion
Immune System
Immunity

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology

Cite this

Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. / Phongsisay, Vongsavanh; Hara, Hiromitsu; Fujimoto, Shuji.

In: Molecular Immunology, Vol. 64, No. 1, 01.03.2015, p. 195-203.

Research output: Contribution to journalArticle

Phongsisay, Vongsavanh ; Hara, Hiromitsu ; Fujimoto, Shuji. / Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. In: Molecular Immunology. 2015 ; Vol. 64, No. 1. pp. 195-203.
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