Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants

Yoshinari Morimoto, Chizuko Yokoe, yuko imai, Megumi Sugihara, Toshiko Futatsuki

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    Background/purpose The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed. Materials and methods The medical charts of these patients were investigated. Tooth extraction was performed while maintaining conventional anticoagulant therapy. Results Twenty-three teeth were extracted in 19 patients, including two surgical extractions. Among the 19 patients, nine patients ingested rivaroxaban, six apixaban, and four dabigatran. One patient on rivaroxaban showed persistent postoperative bleeding following two surgical extractions. Mild oozing was observed in five patients (two on rivaroxaban and three on apixaban). There was no bleeding episode in the patients on dabigatran. Conclusion The patients on rivaroxaban with a prolonged prothrombin time value have a higher risk of bleeding, especially undergoing surgical extraction. Apixaban correlates to neither activated partial thromboplastin time nor prothrombin time values and the countermeasures should be employed based on the clinical findings.

    Original languageEnglish
    Pages (from-to)59-64
    Number of pages6
    JournalJournal of Dental Sciences
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - Mar 1 2016

    Fingerprint

    Tooth Extraction
    Anticoagulants
    Prothrombin Time
    Hemorrhage
    Antithrombins
    Partial Thromboplastin Time
    Tooth
    Rivaroxaban
    apixaban

    All Science Journal Classification (ASJC) codes

    • Dentistry(all)

    Cite this

    Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants. / Morimoto, Yoshinari; Yokoe, Chizuko; imai, yuko; Sugihara, Megumi; Futatsuki, Toshiko.

    In: Journal of Dental Sciences, Vol. 11, No. 1, 01.03.2016, p. 59-64.

    Research output: Contribution to journalArticle

    Morimoto, Yoshinari ; Yokoe, Chizuko ; imai, yuko ; Sugihara, Megumi ; Futatsuki, Toshiko. / Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants. In: Journal of Dental Sciences. 2016 ; Vol. 11, No. 1. pp. 59-64.
    @article{074d1263c45d4fa5842fe8d26551107b,
    title = "Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants",
    abstract = "Background/purpose The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed. Materials and methods The medical charts of these patients were investigated. Tooth extraction was performed while maintaining conventional anticoagulant therapy. Results Twenty-three teeth were extracted in 19 patients, including two surgical extractions. Among the 19 patients, nine patients ingested rivaroxaban, six apixaban, and four dabigatran. One patient on rivaroxaban showed persistent postoperative bleeding following two surgical extractions. Mild oozing was observed in five patients (two on rivaroxaban and three on apixaban). There was no bleeding episode in the patients on dabigatran. Conclusion The patients on rivaroxaban with a prolonged prothrombin time value have a higher risk of bleeding, especially undergoing surgical extraction. Apixaban correlates to neither activated partial thromboplastin time nor prothrombin time values and the countermeasures should be employed based on the clinical findings.",
    author = "Yoshinari Morimoto and Chizuko Yokoe and yuko imai and Megumi Sugihara and Toshiko Futatsuki",
    year = "2016",
    month = "3",
    day = "1",
    doi = "10.1016/j.jds.2015.09.002",
    language = "English",
    volume = "11",
    pages = "59--64",
    journal = "Journal of Dental Sciences",
    issn = "1991-7902",
    publisher = "Association for Dental Sciences of the Republic of China",
    number = "1",

    }

    TY - JOUR

    T1 - Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants

    AU - Morimoto, Yoshinari

    AU - Yokoe, Chizuko

    AU - imai, yuko

    AU - Sugihara, Megumi

    AU - Futatsuki, Toshiko

    PY - 2016/3/1

    Y1 - 2016/3/1

    N2 - Background/purpose The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed. Materials and methods The medical charts of these patients were investigated. Tooth extraction was performed while maintaining conventional anticoagulant therapy. Results Twenty-three teeth were extracted in 19 patients, including two surgical extractions. Among the 19 patients, nine patients ingested rivaroxaban, six apixaban, and four dabigatran. One patient on rivaroxaban showed persistent postoperative bleeding following two surgical extractions. Mild oozing was observed in five patients (two on rivaroxaban and three on apixaban). There was no bleeding episode in the patients on dabigatran. Conclusion The patients on rivaroxaban with a prolonged prothrombin time value have a higher risk of bleeding, especially undergoing surgical extraction. Apixaban correlates to neither activated partial thromboplastin time nor prothrombin time values and the countermeasures should be employed based on the clinical findings.

    AB - Background/purpose The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed. Materials and methods The medical charts of these patients were investigated. Tooth extraction was performed while maintaining conventional anticoagulant therapy. Results Twenty-three teeth were extracted in 19 patients, including two surgical extractions. Among the 19 patients, nine patients ingested rivaroxaban, six apixaban, and four dabigatran. One patient on rivaroxaban showed persistent postoperative bleeding following two surgical extractions. Mild oozing was observed in five patients (two on rivaroxaban and three on apixaban). There was no bleeding episode in the patients on dabigatran. Conclusion The patients on rivaroxaban with a prolonged prothrombin time value have a higher risk of bleeding, especially undergoing surgical extraction. Apixaban correlates to neither activated partial thromboplastin time nor prothrombin time values and the countermeasures should be employed based on the clinical findings.

    UR - http://www.scopus.com/inward/record.url?scp=84959486818&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84959486818&partnerID=8YFLogxK

    U2 - 10.1016/j.jds.2015.09.002

    DO - 10.1016/j.jds.2015.09.002

    M3 - Article

    VL - 11

    SP - 59

    EP - 64

    JO - Journal of Dental Sciences

    JF - Journal of Dental Sciences

    SN - 1991-7902

    IS - 1

    ER -