Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice

Takahito Chiba, S. Takeuchi, H. Esaki, K. Yamamura, Y. Kurihara, Y. Moroi, M. Furue

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which regulate not only adipogenesis and proliferation/ differentiation but also the immune response of cells. Because topical application of the activators of some PPAR isoforms improved clinical symptoms in patients with atopic dermatitis (AD), we investigated the role of PPAR activators using a murine AD model in NC/Nga mice; to the best of our knowledge, this has not been previously reported. Methods: Activators of three PPAR isoforms (α, β/δ, γ) were topically applied on inflamed skin in a murine AD model that was developed by repeated topical application of mite antigen in NC/Nga mice. The efficacy of each topical PPAR activator was evaluated immunologically and serologically. Results: Topical application of the PPARα activator, but not of the activators of PPARβ/δ or PPARγ, improved clinical dermatitis, reduced inflammatory cell infiltration in the dermis, and alleviated the elevation of serum IgE levels. In addition, PPARa expression was downregulated in the epidermis in our murine AD model, as is seen in patients with AD. Conclusions: Topical application of PPARα activator could be a potent therapeutic agent for patients with AD and could take the place of topical steroid treatments.

Original languageEnglish
Pages (from-to)936-942
Number of pages7
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume67
Issue number7
DOIs
Publication statusPublished - Jul 1 2012

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Peroxisome Proliferator-Activated Receptors
Atopic Dermatitis
Protein Isoforms
Adipogenesis
Mites
Proxy
Dermatitis
Dermis
Cytoplasmic and Nuclear Receptors
Epidermis
Immunoglobulin E
Down-Regulation
Steroids
Antigens
Skin

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice. / Chiba, Takahito; Takeuchi, S.; Esaki, H.; Yamamura, K.; Kurihara, Y.; Moroi, Y.; Furue, M.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 67, No. 7, 01.07.2012, p. 936-942.

Research output: Contribution to journalArticle

Chiba, Takahito ; Takeuchi, S. ; Esaki, H. ; Yamamura, K. ; Kurihara, Y. ; Moroi, Y. ; Furue, M. / Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice. In: Allergy: European Journal of Allergy and Clinical Immunology. 2012 ; Vol. 67, No. 7. pp. 936-942.
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