Abstract
Objectives: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are widely used for hyperlipidemia. Recent studies demonstrate that statins stimulate bone morphogenetic protein-2 expression and lead to bone formation. The aim of this study was to evaluate whether the topical application of statin enhances the osteogenesis around a titanium implant. Materials and methods: Ten-week-old female rats received pure titanium rods in both tibiae with or without fluvastatin. Propylene glycol alginate (PGA) was used as a carrier. The rats were divided into five groups: implant-only group, implant with PGA group, low-dose group [implant+PGA containing 3 μg of fluvastatin (FS)], medium-dose group (15 μg of FS), and high-dose group (75 μg of FS). The animals were sacrificed at 1 and 2 weeks after implantation. Peri-implant bone formation was assessed by histomorphometric procedures, i.e., measuring the bone-implant contact (BIC) and peri-implant bone volume (BV). A mechanical push-out test was also performed to evaluate the implant fixation strength. Statistical differences among the groups were determined by ANOVA and P<0.05 was considered significant. Results: At week 1, there was no significant difference in BIC among the groups, however, BV and the push-out strength were significantly higher in the high-dose group than in the implant-only group. At week 2, BIC and BV had significantly increased in the high-dose group in comparison with the non-statin groups. The fluvastatin-treatment group showed a significant increase in push-out strength compared with the non-statin groups. Conclusion: Our histomorphometrical and mechanical evaluations revealed the positive effect of topically applied fluvastatin on the bone around the implant.
| Original language | English |
|---|---|
| Pages (from-to) | 600-605 |
| Number of pages | 6 |
| Journal | Clinical Oral Implants Research |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2008 |
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All Science Journal Classification (ASJC) codes
- Oral Surgery
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Topical application of statin affects bone healing around implants. / Moriyama, Yasuko; Ayukawa, Yasunori; Ogino, Yoichiro; Atsuta, Ikiru; Koyano, Kiyoshi.
In: Clinical Oral Implants Research, Vol. 19, No. 6, 01.06.2008, p. 600-605.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical application of statin affects bone healing around implants
AU - Moriyama, Yasuko
AU - Ayukawa, Yasunori
AU - Ogino, Yoichiro
AU - Atsuta, Ikiru
AU - Koyano, Kiyoshi
PY - 2008/6/1
Y1 - 2008/6/1
N2 - Objectives: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are widely used for hyperlipidemia. Recent studies demonstrate that statins stimulate bone morphogenetic protein-2 expression and lead to bone formation. The aim of this study was to evaluate whether the topical application of statin enhances the osteogenesis around a titanium implant. Materials and methods: Ten-week-old female rats received pure titanium rods in both tibiae with or without fluvastatin. Propylene glycol alginate (PGA) was used as a carrier. The rats were divided into five groups: implant-only group, implant with PGA group, low-dose group [implant+PGA containing 3 μg of fluvastatin (FS)], medium-dose group (15 μg of FS), and high-dose group (75 μg of FS). The animals were sacrificed at 1 and 2 weeks after implantation. Peri-implant bone formation was assessed by histomorphometric procedures, i.e., measuring the bone-implant contact (BIC) and peri-implant bone volume (BV). A mechanical push-out test was also performed to evaluate the implant fixation strength. Statistical differences among the groups were determined by ANOVA and P<0.05 was considered significant. Results: At week 1, there was no significant difference in BIC among the groups, however, BV and the push-out strength were significantly higher in the high-dose group than in the implant-only group. At week 2, BIC and BV had significantly increased in the high-dose group in comparison with the non-statin groups. The fluvastatin-treatment group showed a significant increase in push-out strength compared with the non-statin groups. Conclusion: Our histomorphometrical and mechanical evaluations revealed the positive effect of topically applied fluvastatin on the bone around the implant.
AB - Objectives: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are widely used for hyperlipidemia. Recent studies demonstrate that statins stimulate bone morphogenetic protein-2 expression and lead to bone formation. The aim of this study was to evaluate whether the topical application of statin enhances the osteogenesis around a titanium implant. Materials and methods: Ten-week-old female rats received pure titanium rods in both tibiae with or without fluvastatin. Propylene glycol alginate (PGA) was used as a carrier. The rats were divided into five groups: implant-only group, implant with PGA group, low-dose group [implant+PGA containing 3 μg of fluvastatin (FS)], medium-dose group (15 μg of FS), and high-dose group (75 μg of FS). The animals were sacrificed at 1 and 2 weeks after implantation. Peri-implant bone formation was assessed by histomorphometric procedures, i.e., measuring the bone-implant contact (BIC) and peri-implant bone volume (BV). A mechanical push-out test was also performed to evaluate the implant fixation strength. Statistical differences among the groups were determined by ANOVA and P<0.05 was considered significant. Results: At week 1, there was no significant difference in BIC among the groups, however, BV and the push-out strength were significantly higher in the high-dose group than in the implant-only group. At week 2, BIC and BV had significantly increased in the high-dose group in comparison with the non-statin groups. The fluvastatin-treatment group showed a significant increase in push-out strength compared with the non-statin groups. Conclusion: Our histomorphometrical and mechanical evaluations revealed the positive effect of topically applied fluvastatin on the bone around the implant.
UR - http://www.scopus.com/inward/record.url?scp=43449123333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43449123333&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0501.2007.01508.x
DO - 10.1111/j.1600-0501.2007.01508.x
M3 - Article
C2 - 18422989
AN - SCOPUS:43449123333
VL - 19
SP - 600
EP - 605
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
SN - 0905-7161
IS - 6
ER -