Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption

Takahiro Arimura, Keita Saku, Takamori Kakino, Takuya Akashi, Takako Takehara, Akiko Nishizaki, Yasuhiro Oga, Masataka Ikeda, Kana Fujii, Tomomi Ide, Takuya Kishi, Kenji Sunagawa

Research output: Contribution to journalArticle

Abstract

Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.

Original languageEnglish
Pages (from-to)O-548-O-549
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Left ventricular assist devices
Unloading
Oxygen
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption. / Arimura, Takahiro; Saku, Keita; Kakino, Takamori; Akashi, Takuya; Takehara, Takako; Nishizaki, Akiko; Oga, Yasuhiro; Ikeda, Masataka; Fujii, Kana; Ide, Tomomi; Kishi, Takuya; Sunagawa, Kenji.

In: Transactions of Japanese Society for Medical and Biological Engineering, Vol. 52, 01.01.2014, p. O-548-O-549.

Research output: Contribution to journalArticle

Arimura, T, Saku, K, Kakino, T, Akashi, T, Takehara, T, Nishizaki, A, Oga, Y, Ikeda, M, Fujii, K, Ide, T, Kishi, T & Sunagawa, K 2014, 'Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption', Transactions of Japanese Society for Medical and Biological Engineering, vol. 52, pp. O-548-O-549. https://doi.org/10.11239/jsmbe.52.O-548
Arimura, Takahiro ; Saku, Keita ; Kakino, Takamori ; Akashi, Takuya ; Takehara, Takako ; Nishizaki, Akiko ; Oga, Yasuhiro ; Ikeda, Masataka ; Fujii, Kana ; Ide, Tomomi ; Kishi, Takuya ; Sunagawa, Kenji. / Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption. In: Transactions of Japanese Society for Medical and Biological Engineering. 2014 ; Vol. 52. pp. O-548-O-549.
@article{dc88e629b8804b04a64e71106399aeed,
title = "Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption",
abstract = "Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.",
author = "Takahiro Arimura and Keita Saku and Takamori Kakino and Takuya Akashi and Takako Takehara and Akiko Nishizaki and Yasuhiro Oga and Masataka Ikeda and Kana Fujii and Tomomi Ide and Takuya Kishi and Kenji Sunagawa",
year = "2014",
month = "1",
day = "1",
doi = "10.11239/jsmbe.52.O-548",
language = "English",
volume = "52",
pages = "O--548--O--549",
journal = "BME = Bio medical engineering / henshu, Nihon ME Gakkai",
issn = "1347-443X",
publisher = "Japanese Society for Medical and Biological Engineering",

}

TY - JOUR

T1 - Total left ventricular unloading markedly reduces the pressure-volume area, thereby oxygen consumption

AU - Arimura, Takahiro

AU - Saku, Keita

AU - Kakino, Takamori

AU - Akashi, Takuya

AU - Takehara, Takako

AU - Nishizaki, Akiko

AU - Oga, Yasuhiro

AU - Ikeda, Masataka

AU - Fujii, Kana

AU - Ide, Tomomi

AU - Kishi, Takuya

AU - Sunagawa, Kenji

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.

AB - Left ventricular assist device (LVAD) unloads LV and exerts better outcome in both acute coronary syndrome and severe heart failure. In this study, we investigate how the degree of LVAD support impacts on the hemodynamics and oxygen consumption of left ventricle. Methods/Results: We used 5 dogs and changed LVAD support at 3 levels, no support, Partial (LV remains ejecting) and Total (total LVAD dependent circulation). Mean aortic pressure were not different among 3 groups, while peak systolic pressure of LV reduced in Total (108±8.6 vs 102±3.3 vs 42±11mmHg, p<0.05). The pressure-volume area (PVA) indicating oxygen consumption of LV significantly reduced in Partial, while markedly reduced in Total (2040±632 vs 1787±547 vs 487±160 ml·mmHg, p<0.05). Conclusions: Total unloading minimizes oxygen consumption of left ventricle. Appropriate unloading minimizes oxygen consumption and enables us to maximize the beneficial effect of LVAD in heart disease.

UR - http://www.scopus.com/inward/record.url?scp=84939451350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939451350&partnerID=8YFLogxK

U2 - 10.11239/jsmbe.52.O-548

DO - 10.11239/jsmbe.52.O-548

M3 - Article

VL - 52

SP - O-548-O-549

JO - BME = Bio medical engineering / henshu, Nihon ME Gakkai

JF - BME = Bio medical engineering / henshu, Nihon ME Gakkai

SN - 1347-443X

ER -