Total synthesis of (-)-aspidospermine via diastereoselective ring-closing olefin metathesis

Yu Ichi Fukuda, Mitsuru Shindo, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

(Matrix presented) An enantiocontrolled total synthesis of (-)-aspidospermine has been achieved. The key element of the strategy is the diastereoselective construction of the quaternary stereogenic center employing 1,4-asymmetric induction during the ring-closing olefin metathesis.

Original languageEnglish
Pages (from-to)749-751
Number of pages3
JournalOrganic Letters
Volume5
Issue number5
DOIs
Publication statusPublished - Mar 6 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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