Abstract
(Chemical Equation Presented) Total synthesis of (-)-brevenal, a novel marine polycyclic ether natural product, is described. Highly efficient and scalable entries to the AB-ring exo-olefin and the DE-ring enol phosphate and a rapid construction of the C-ring by means of our Suzuki-Miyaura coupling-based strategy realized a concise synthesis of the pentacyclic skeleton of (-)-brevenal. The present synthesis is considerably more efficient than our previous synthesis (longest linear sequence: 50 steps from 2-deoxy-D-ribose).
Original language | English |
---|---|
Pages (from-to) | 2275-2278 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 10 |
Issue number | 11 |
DOIs | |
Publication status | Published - Jun 5 2008 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry