Total synthesis of ciguatoxin CTX3C

M. Hirama, T. Oishi, H. Uehara, M. Inoue, M. Maruyama, H. Oguri, M. Satake

Research output: Contribution to journalArticlepeer-review

229 Citations (Scopus)

Abstract

More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins. The large (3 nanometers long) and complicated molecular structure of ciguatoxins has impeded chemists from completing their total synthesis. Our highly convergent strategic approach featuring the chemoselective ring-closing metathesis reaction as a key tactic has enabled the total synthesis of ciguatoxin CTX3C, which will provide a practical supply for further studies.

Original languageEnglish
Pages (from-to)1904-1907
Number of pages4
JournalScience
Volume294
Issue number5548
DOIs
Publication statusPublished - Nov 30 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Total synthesis of ciguatoxin CTX3C'. Together they form a unique fingerprint.

Cite this