Total synthesis of the proposed structure of brevenal, a natural marine polycyclic ether product, has been accomplished. The synthesis features (i) convergent synthesis of the pentacyclic polyether skeleton using our developed Suzuki-Miyaura coupling strategy and (ii) construction of the multi-substituted dienal side chain by CuTC-mediated Stille reaction. Comparison of the NMR data of the synthetic compound with those reported for the natural product revealed that the proposed structure of brevenal needs to be revised.
|Number of pages||3|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - Aug 2 2006|
All Science Journal Classification (ASJC) codes
- Colloid and Surface Chemistry