TY - JOUR
T1 - Total synthesis of xanthanolides
AU - Matsuo, Kazumasa
AU - Ohtsuki, Keiko
AU - Yoshikawa, Takashi
AU - Shishido, Kozo
AU - Yokotani-Tomita, Kaori
AU - Shindo, Mitsuru
N1 - Funding Information:
This research was partially supported by a Grant-in-Aid for Scientific Research on (B) ( 19390007, 22390002 ) and the Program for Promotion of Basic and Applied Research for Innovations in the Bio-oriented Industry (BRAIN). K.M. additionally acknowledges the support of the JSPS. We are also grateful to Ms. C. Moriya for experimental contribution in the early stage of this project.
PY - 2010/10/23
Y1 - 2010/10/23
N2 - The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide.
AB - The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide.
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U2 - 10.1016/j.tet.2010.08.061
DO - 10.1016/j.tet.2010.08.061
M3 - Article
AN - SCOPUS:77957344294
VL - 66
SP - 8407
EP - 8419
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 43
ER -