Abstract
The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide.
| Original language | English |
|---|---|
| Pages (from-to) | 8407-8419 |
| Number of pages | 13 |
| Journal | Tetrahedron |
| Volume | 66 |
| Issue number | 43 |
| DOIs | |
| Publication status | Published - Oct 23 2010 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Total synthesis of xanthanolides. / Matsuo, Kazumasa; Ohtsuki, Keiko; Yoshikawa, Takashi; Shishido, Kozo; Yokotani-Tomita, Kaori; Shindo, Mitsuru.
In: Tetrahedron, Vol. 66, No. 43, 23.10.2010, p. 8407-8419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Total synthesis of xanthanolides
AU - Matsuo, Kazumasa
AU - Ohtsuki, Keiko
AU - Yoshikawa, Takashi
AU - Shishido, Kozo
AU - Yokotani-Tomita, Kaori
AU - Shindo, Mitsuru
PY - 2010/10/23
Y1 - 2010/10/23
N2 - The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide.
AB - The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide.
UR - http://www.scopus.com/inward/record.url?scp=77957344294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957344294&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2010.08.061
DO - 10.1016/j.tet.2010.08.061
M3 - Article
AN - SCOPUS:77957344294
VL - 66
SP - 8407
EP - 8419
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 43
ER -