Towards an electronic dog nose: Surface plasmon resonance immunosensor for security and safety

Takeshi Onodera, Kiyoshi Toko

Research output: Contribution to journalReview article

24 Citations (Scopus)


This review describes an “electronic dog nose” based on a surface plasmon resonance (SPR) sensor and an antigen–antibody interaction for security and safety. We have concentrated on developing appropriate sensor surfaces for the SPR sensor for practical use. The review covers different surface fabrications, which all include variations of a self-assembled monolayer containing oligo(ethylene glycol), dendrimer, and hydrophilic polymer. We have carried out detection of explosives using the sensor surfaces. For the SPR sensor to detect explosives, the vapor or particles of the target substances have to be dissolved in a liquid. Therefore, we also review the development of sampling processes for explosives, and a protocol for the measurement of explosives on the SPR sensor in the field. Additionally, sensing elements, which have the potential to be applied for the electronic dog nose, are described.

Original languageEnglish
Pages (from-to)16586-16616
Number of pages31
JournalSensors (Switzerland)
Issue number9
Publication statusPublished - Sep 5 2014


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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