Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Utako Oba, Hiroshi Yamada, So Ichi Suenobu, Yusuke Nakamura, Akiko Ito, Yutaka Hatano, Nobuyoshi Itonaga, Kouichi Ohshima, Yuhki Koga, Shoichi Ohga, Kenji Ihara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

Original languageEnglish
Article numbere12931
JournalPediatric Transplantation
Volume21
Issue number5
DOIs
Publication statusPublished - Aug 1 2017

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Stevens-Johnson Syndrome
Hematopoietic Stem Cell Transplantation
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
Rare Diseases
Keratinocytes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemokines
Pediatrics
Apoptosis
Cytokines
Skin
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Oba, U., Yamada, H., Suenobu, S. I., Nakamura, Y., Ito, A., Hatano, Y., ... Ihara, K. (2017). Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation. Pediatric Transplantation, 21(5), [e12931]. https://doi.org/10.1111/petr.12931

Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation. / Oba, Utako; Yamada, Hiroshi; Suenobu, So Ichi; Nakamura, Yusuke; Ito, Akiko; Hatano, Yutaka; Itonaga, Nobuyoshi; Ohshima, Kouichi; Koga, Yuhki; Ohga, Shoichi; Ihara, Kenji.

In: Pediatric Transplantation, Vol. 21, No. 5, e12931, 01.08.2017.

Research output: Contribution to journalArticle

Oba, U, Yamada, H, Suenobu, SI, Nakamura, Y, Ito, A, Hatano, Y, Itonaga, N, Ohshima, K, Koga, Y, Ohga, S & Ihara, K 2017, 'Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation', Pediatric Transplantation, vol. 21, no. 5, e12931. https://doi.org/10.1111/petr.12931
Oba, Utako ; Yamada, Hiroshi ; Suenobu, So Ichi ; Nakamura, Yusuke ; Ito, Akiko ; Hatano, Yutaka ; Itonaga, Nobuyoshi ; Ohshima, Kouichi ; Koga, Yuhki ; Ohga, Shoichi ; Ihara, Kenji. / Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation. In: Pediatric Transplantation. 2017 ; Vol. 21, No. 5.
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AU - Itonaga, Nobuyoshi

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