Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation

Utako Oba, Hiroshi Yamada, So Ichi Suenobu, Yusuke Nakamura, Akiko Ito, Yutaka Hatano, Nobuyoshi Itonaga, Kouichi Ohshima, Yuhki Koga, Shouichi Ohga, Kenji Ihara

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Abstract

TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN.

Original languageEnglish
Article numbere12931
JournalPediatric Transplantation
Volume21
Issue number5
DOIs
Publication statusPublished - Aug 2017

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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    Oba, U., Yamada, H., Suenobu, S. I., Nakamura, Y., Ito, A., Hatano, Y., Itonaga, N., Ohshima, K., Koga, Y., Ohga, S., & Ihara, K. (2017). Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation. Pediatric Transplantation, 21(5), [e12931]. https://doi.org/10.1111/petr.12931